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FLASH GENE
Symbol INADL contributors: mct/pgu - updated : 11-05-2011
HGNC name InaD-like (Drosophila)
HGNC id 28881
Location 1p31.3      Physical location : 62.208.148 - 62.629.589
Synonym name
  • Drosophila INAD-like
  • Pals1-associated tight junction protein
  • PALS1-associated TJ protein
  • PDZ domain protein (Drosophila inaD-like)
  • inactivation no after-potential D-like protein
  • Synonym symbol(s) PATJ, Cipp, FLJ26982
    DNA
    TYPE functioning gene
    STRUCTURE 421.44 kb     43 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    Map pter - D1S2741 - INADL - CYP2J2 - TACSTD2 - D1S220 - D1S2770 - D1S2873 - D1S203 - cen
    Authors GeneMap (99)
    RNA
    TRANSCRIPTS type messenger
    text two truncated forms
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4863 173.8 1582 - 2001 11509564
    43 - 8505 - 1801 - 2001 11509564
    35 - 4773 170.3 1552 - 2001 11509564
    - - 5349 167.2 1524 - 2001 11509564
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
    Nervousbrain    
    Respiratoryrespiratory tractlarynx  highly
     respiratory tracttrachea  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentepidermal secretory cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eight PDZ domains
  • C-terminal PDZ binding motif
  • HOMOLOGY
    interspecies ortholog to Drosophila Disc lost
    ortholog to murine Inadl
    Homologene
    FAMILY
    CATEGORY storage
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
        intracellular
    intracellular,cytoplasm,organelle,endosome
    text
  • directly binding with AMOT redistributes INADL and its binding partners from the plasma membrane to endosomes
  • basic FUNCTION
  • tight junction-associated multi-PDZ protein
  • degradation target of high-risk human papillomavirus E6 and the alternatively spliced isoform 18 E6
  • regulates directional migration of mammalian epithelial cells
  • plays a novel role in the building of tight junctions by providing a link between their lateral and apical components
  • necessary for the stability of the Crb complex at the stalk membrane and is crucial for stalk membrane development and rhabdomere maintenance during late pupal stages
  • protects against light-induced photoreceptor degeneration
  • scaffold organizer protein linking dopamine and angiotensin II to the regulation of sodium transport in renal epithelial cells
  • TAZ and INADL are novel regulatory elements of the PKD2 channel and might thus be involved in ADPKD pathology
  • precise balance between MPDZ and INADL is achieved in epithelial cells by regulating their association with MPP5
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a complex with CRB1 and MMP5 : 6
  • AMOT forms a ternary complex together with INADL (or its paralogue MPDZ) and PLEKHG5, involved in directional migration of capillaries in the embryo
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CRB1, CRB2, MPP5, MPP6
  • TJP3 can associate with INADL (INADL/TJP3 interaction is likely important for recruiting INADL and its associated proteins to tight junctions)
  • interaction partner of WWC1 (the last four AAs of WWC1 mediated binding to the eighth PDZ domain of INADL)
  • interacting with BAIAP2 (
  • interacting with proteins involved in cytoskeletal dynamics (Alpi 2009)
  • interaction with MPDZ (INADL is indispensable for the establishment of tight junctions and epithelial polarization, whereas MPDZ is not)
  • AMOT directly binds the scaffolding proteins INADL and MPDZ and redistributes them and their binding partners from the plasma membrane to endosomes
  • interaction of TAZ with the multi-PDZ-containing PALS1-associated tight junction protein (INADL)
  • C terminus of PKD2 strongly interacts with PDZ domains 8-10 and to a weaker extent with PDZ domains 1-3 of INADL
  • MPDZ and INADL are closely related scaffold proteins and bind to many common interactors including MPP5 (protein associated with Lin seven) a member of the Crumbs complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS