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FLASH GENE
Symbol INA contributors: npt/mct - updated : 08-12-2020
HGNC name internexin neuronal intermediate filament protein, alpha
HGNC id 6057
Corresponding disease
NIFID neuronal intermediate filament inclusion disease
Location 10q24.33      Physical location : 105.036.919 - 105.050.106
Synonym name
  • TAX-binding protein
  • neurofilament 5.66 KDa
  • neurofilament-66
  • alpha-internexin
    • Synonym symbol(s) NEF5, TXBP1, AINX, NF-66, MGC12702, FLJ18662, FLJ57501
    DNA
    TYPE functioning gene
    STRUCTURE 13.20 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3245 - 499 - Armstrong (2006)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Endocrinepancreas   highly
    Nervousbrainforebraincerebral lobefrontalhighly
    Respiratorylung   moderately
    Visualeyeretina  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain, eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Ina
    Homologene
    FAMILY
  • intermediate filament family, type IV
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • involved in the morphogenesis of neurons
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NIFID
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in Parkinson disease (PD)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS