Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol IMPG1 contributors: /mct - updated : 17-10-2013
HGNC name interphotoreceptor matrix proteoglycan 1
HGNC id 6055
Corresponding disease
BCAMD1 benign concentric annular macular dystrophy 1
VMD3 macular dystrophy, vitelliform 3
Location 6q14.1      Physical location : 76.631.061 - 76.782.335
Synonym name
  • sialoprotein associated with cones and rods
  • interphotoreceptor matrix proteoglycan of 150 kDa
  • Synonym symbol(s) IPM150, SPACR, GP147
    DNA
    TYPE functioning gene
    STRUCTURE 151.27 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - D6S313 - STGD3 - D6S252 - D6S249 - IMPG1 ,MCDR1 - D6S1671 - PBCRA1 - D6S301- qter
    Authors Felbor (98)
    Physical map
    LOC340168 6q14.1 similar to developmental pluripotency associated 5; embryonal stem cell specific gene 1 LOC154288 6q14.1 similar to RIKEN cDNA 2410004A20 RPL39P3 6q14.1 ribosomal protein L39 pseudogene 3 DDX43 6q12-q13 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 C6orf150 6q13 chromosome 6 open reading frame 150 MTO1 6q14.1 mitochondrial translation optimization 1 homolog (S. cerevisiae) EEF1A1 6q14 eukaryotic translation elongation factor 1 alpha 1 LOC389411 6 LOC389411 SLC17A5 6q14-q15 solute carrier family 17 (anion/sugar transporter), member 5 CD109 6q14.1 CD109 antigen (Gov platelet alloantigens) COL12A1 6q12-q13 collagen, type XII, alpha 1 COX7A2 6q12 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) C6orf67 6q14.1 chromosome 6 open reading frame 67 FILIP1 6q14.1 filamin A interacting protein 1 SUSP1 6q13-q14.3 filamin A interacting protein 1 MYO6 6q13 myosin VI IMPG1 6q14.2-q15 interphotoreceptor matrix proteoglycan 1 HTR1B 6q13 5-hydroxytryptamine (serotonin) receptor 1B
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 3268 89.25 797 - 2000 10937595
    - - 3342 - 719 - 2000 10937595
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain    
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousoptic nerve
    Visualcone photoreceptor
    Visualrod photoreceptor
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye, anterior segment,retina foveal macular,optic nerve
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • functional hyaluronan binding domain and not etablished glycosaminoglycan attachment site
  • three sites for N glycosylation
  • two SEA domains (after sea urchin sperm protein, enterokinase, and agrin), a highly conserved structure composed of four anti-parallel beta sheets surrounded by alpha helices
  • a central mucin-like domain
  • an EGF-like domain in the C-terminal region
  • conjugated GlycoP , Other
    HOMOLOGY
    Homologene
    FAMILY
  • extracellular matrix glycoconjugates family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    text photoreceptor layer including IPM, cone pedicles, rod spherules
    basic FUNCTION
  • participating in retinal adhesion and in maintaining photoreceptor viability
  • photoreceptor cell-associated chondroitin-sulfate proteoglycan
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of interphotoreceptor matrix, associated with cones and rods
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • with IMPG2, bind to hyaluronan, a glycosaminoglycan molecule that is essential for the organization of the interphotoreceptor matrix (Bandah-Rozenfeld 2010)
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BCAMD1 , VMD3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS