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FLASH GENE
Symbol IMP4 contributors: - updated : 07-09-2006
HGNC name IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
HGNC id 30856
Location 2q21.1      Physical location : 131.100.488 - 131.104.197
Synonym name
  • U3 snoRNP protein IMP4
  • brix domain-containing protein 4
    • Synonym symbol(s) MGC19606, BXDC4
    DNA
    TYPE functioning gene
    STRUCTURE 3.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Lymphoid/Immunelymph node    
     spleen    
     tonsils    
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one Brix domain
    • conjugated RiboP
    HOMOLOGY
    interspecies homolog to murine Imp4 (97.3pc)
    homolog to rattus Imp4 (97.9pc)
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • required for the early cleavages during pre-18S ribosomal RNA processing
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP)
  • component of a heterotrimeric complex containing IMP3, IMP4 and KIF20B
    • INTERACTION
    DNA
    RNA binding
    small molecule
    protein interacting with KIF20B
    cell & other
    REGULATION
    Other the formation of the ternary complex of IMP3, IMP4 and MPP10 is required for their association with nucleolar components
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS