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FLASH GENE
Symbol IMP4 contributors: - updated : 07-09-2006
HGNC name IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
HGNC id 30856
Location 2q21.1      Physical location : 131.100.488 - 131.104.197
Synonym name
  • U3 snoRNP protein IMP4
  • brix domain-containing protein 4
  • Synonym symbol(s) MGC19606, BXDC4
    DNA
    TYPE functioning gene
    STRUCTURE 3.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391434 2 similar to hypothetical protein DKFZp434P0316 LOC389033 2 LOC389033 LOC150516 2q21.1 RAB6C, member RAS oncogene family pseudogene LOC285100 2q21.1 similar to Lck-associated signal transducer LAST LOC285101 2q21.1 similar to Oligophrenin 1 LOC389034 2 similar to hypothetical protein A230046P18 LOC344227 2q21.2 similar to pote protein; Expressed in prostate, ovary, testis, and placenta DKFZp434E2321 2q21.2 hypothetical protein DKFZp434E2321 FLJ20297 2q21.2 hypothetical protein FLJ20297 FLJ14346 2q21.2 hypothetical protein FLJ14346 LOC112714 2q21.2 similar to alpha tubulin LOC391435 2 hypothetical gene supported by NM_012249 LOC389035 2 hypothetical gene supported by BC060851 LOC391436 2 similar to positive cofactor 2, glutamine/Q-rich-associated protein; TPA inducible protein; TPA inducible gene-1; PC2-glutamine-rich-associated protein; trinucleotide repeat containing 7 LOC391437 2 similar to ribosomal protein L19 MGC12981 2q21.2 hypothetical protein MGC12981 IMP4 2q21.2 U3 snoRNP protein 4 homolog PTPN18 2p14-q14.3 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) LOC391438 2 similar to hypothetical protein A230046P18 LOC391439 2 similar to hypothetical protein DKFZp434F1719 LOC389036 2 similar to FKSG30 LOC389037 2 similar to pote protein; Expressed in prostate, ovary, testis, and placenta CRYPTIC 2q21.1 similar to pote protein; Expressed in prostate, ovary, testis, and placenta LOC391440 2 similar to testicular serine protease 1 LOC391441 2 similar to testicular serine protease 1 LOC391442 2 similar to FKSG30 DKFZp434F1719 LOC150519 2q21.2 similar to hypothetical protein A230046P18 GPR148 2q21.2 G protein-coupled receptor 148 FLJ38377 2q21.2 hypothetical protein FLJ38377 HCP8 2q21.1 cytochrome c, somatic pseudogene LOC389038 2 LOC389038 ARHGEF4 2q22 Rho guanine nucleotide exchange factor (GEF) 4
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Lymphoid/Immunelymph node    
     spleen    
     tonsils    
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one Brix domain
  • conjugated RiboP
    HOMOLOGY
    interspecies homolog to murine Imp4 (97.3pc)
    homolog to rattus Imp4 (97.9pc)
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • required for the early cleavages during pre-18S ribosomal RNA processing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP)
  • component of a heterotrimeric complex containing IMP3, IMP4 and KIF20B
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein interacting with KIF20B
    cell & other
    REGULATION
    Other the formation of the ternary complex of IMP3, IMP4 and MPP10 is required for their association with nucleolar components
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS