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FLASH GENE
Symbol IMP3 contributors: mct - updated : 30-08-2016
HGNC name IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
HGNC id 14497
Location 15q24.2      Physical location : 75.931.425 - 75.932.664
Synonym name
  • mitochondrial ribosomal protein S4
  • chromosome 15 open reading frame 12
  • U3 snoRNP protein IMP3
    • Synonym symbol(s) FLJ10968, BRMS2, MRPS4, C15orf12
    DNA
    TYPE functioning gene
    STRUCTURE 1.24 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1255 - 184 - 2003 12655004
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Lymphoid/Immunetonsils    
    Reproductivefemale systemuteruscervix  
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervous    
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a S4 RNA-binding domain
    • conjugated RiboP
    mono polymer heteromer , trimer , complex
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Imp3p
    homolog to murine Imp3 (96.2pc)
    Homologene
    FAMILY
  • ribosomal protein S4P family
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • required for the early cleavages during pre-18S ribosomal RNA processing
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP)
  • component of a heterotrimeric complex containing IMP3, IMP4 and KIF20B
    • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacting with the U3 snoRNP complex
  • interacting with KIF20B
  • IMP3 facilitates the transcription of SNAI2, which is necessary for TAZ nuclear localization and activation, by a mechanism that is also mediated by WNT5B
    • cell & other
    REGULATION
    Other the formation of the ternary complex of IMP3, IMP4 and MPP10 is required for their association with nucleolar components
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS