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FLASH GENE
Symbol IMMP2L contributors: mct - updated : 06-09-2011
HGNC name IMP2 inner mitochondrial membrane protease-like (S. cerevisiae)
HGNC id 14598
Corresponding disease
GTS7 Tourette syndrome, chromosome 7 related
Location 7q31      Physical location : 110.303.109 - 111.202.347
Synonym name inner mitochondrial membrane peptidase 2 like
Synonym symbol(s) OCD4, IMP2
DNA
TYPE functioning gene
STRUCTURE 899.00 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D7S2504 - D7S2425 - D7S2456 - NRCAM - D7S692 - IMMP2L - D7S623 - D7S522 - qter
Authors Petek (01)
Physical map
SLC26A4 7q31.1 solute carrier family 26, member 4 CBLL1 7q22.3 Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1 SLC26A3 7q33 solute carrier family 26, member 3 DLD 7q31-q32 dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex) LAMB1 7q22.1 laminin, beta 1 LAMB4 7q22-q31.2 laminin, beta 4 NRCAM 7q31.1-q31.2 neuronal cell adhesion molecule IPLA2(GAMMA) 7q31 intracellular membrane-associated calcium-independent phospholipase A2 gamma THAP5 7q22.3 THAP domain containing 5 DNAJB9 14q24.2-q24.3 DnaJ (Hsp40) homolog, subfamily B, member 9 LOC154907 7q22.3 hypothetical LOC154907 LOC392090 7 similar to TGF-beta receptor binding protein LOC392091 7 similar to ribosomal protein L3; 60S ribosomal protein L3; HIV-1 TAR RNA-binding protein B IMMP2L 7q31 IMP2 inner mitochondrial membrane protease-like (S. cerevisiae) LRRN3 7q21.12 leucine rich repeat neuronal 3 LOC392092 7 similar to Argininosuccinate synthase (Citrulline--aspartate ligase) DOCK4 7q21.13-q31.1 similar to Argininosuccinate synthase (Citrulline--aspartate ligase) ZNF277 7q31.1 zinc finger protein (C2H2 type) 277 IFRD1 7q31 interferon-related developmental regulator 1 FLJ39575 7q31.1 hypothetical protein FLJ39575 NPM1P14 7q31.1 nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 14 FLJ13576 7q31.32 hypothetical protein FLJ13576 FLJ31818 7q31.1 hypothetical protein FLJ31818 GPR85 7q31 G protein-coupled receptor 85 LOC389548 7 hypothetical gene supported by BX537645
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  moderately
Reproductivefemale systemplacenta  moderately
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion blood
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N terminal transmembrane domain
  • a signal peptidase 1 domain (anchored in the cytoplasmic membrane, removing the signal peptides from secretory proteins)
  • HOMOLOGY
    interspecies homolog to yeast imp2
    ortholog to murine Immp2l
    ortholog to chicken immp2l
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • acting as a serine-type peptidase
  • involved in folliculogenesis or male fertility
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GTS7
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    dysruption of the gene in 1 case of Gilles de la Tourette syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS