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FLASH GENE
Symbol ILKAP contributors: mct/npt/shn - updated : 24-09-2012
HGNC name integrin-linked kinase-associated serine/threonine phosphatase
HGNC id 15566
Location 2q37.3      Physical location : 239.079.043 - 239.112.324
Synonym name
  • protein phosphatase 2C, delta isozyme
  • integrin-linked kinase-associated serine/threonine phosphatase 2C
  • integrin-linked kinase associated phosphatase
  • Synonym symbol(s) PP2C-delta, FLJ10181, DKFZP434J2031, MGC4846, ILKAP2, ILKAP3, PP2C-DELTA
    EC.number 3.1.3.16
    DNA
    TYPE functioning gene
    STRUCTURE 33.28 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D2S2968 - D2S2338 - ILKAP - D2S2285 - D2S2253 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1480 - 392 - Kumar (2004)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to Ilkap, Mus musculus
    ortholog to Ilkap, Rattus norvegicus
    ortholog to ILKAP, Pan troglodytes
    Homologene
    FAMILY
  • protein phosphatase (PP2C) family
  • CATEGORY adhesion , enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation
  • acts to control the cross-talk between integrin-induced and TNFalpha-induced signaling pathways, inhibiting the former and stimulating the latter, thereby inhibiting proliferation and survival and promoting the apoptosis of cancer cells (Tamura 2006)
  • playing an important role in inhibiting oncogenic transformation
  • function as tumor suppressor protein, and important physiological regulator of cell growth and of cellular stress signaling (Lammers 2007)
  • plays key roles in a variety of cell functions, including cell proliferation, adhesion and migration (Nakrieko 2008)
  • with XPO1, are pivotal modulators of ILK subcellular distribution and activity in the keratinocytes (Nakrieko 2008)
  • CELLULAR PROCESS cell cycle, progression
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • magnesium Mg2+
  • manganese Mn2+
  • protein
  • integrin-linked kinase 1, ILK1
  • PALLD
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS