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FLASH GENE
Symbol ILF3 contributors: mct/npt/pgu - updated : 18-08-2015
HGNC name interleukin enhancer binding factor 3, 90kDa
HGNC id 6038
Location 19p13.2      Physical location : 10.764.936 - 10.803.093
Synonym name
  • M phase phosphoprotein 4, nuclear factor associated with DS RNA
  • double-stranded RNA-binding protein, 76 kD
  • dsRNA binding protein NFAR-2/MPP4
  • nuclear factor of activated T-cells, 90 kD
  • translational control protein 80
  • Synonym symbol(s) NF90, MPP4, NFAR-1, MPHOSPH4 , TCP110, TCP80, DRBF, DRBP76, MMP4, NFAR-2, NF-AT-90
    DNA
    TYPE functioning gene
    STRUCTURE 38.16 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ11286 19p13.2 hypothetical protein FLJ11286 ANGPTL6 19p13.2 angiopoietin-like 6 PPAN 19p13 peter pan homolog (Drosophila) P2RY11 19p13.2 purinergic receptor P2Y, G-protein coupled, 11 EIF3S4 19p13.2 eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa DNMT1 19p13.2 DNA (cytosine-5-)-methyltransferase 1 EDG5 19p13.2 endothelial differentiation, sphingolipid G-protein-coupled receptor, 5 LOC388504 19 LOC388504 MRPL4 19p13.2 mitochondrial ribosomal protein L4 ICAM1 19p13.3-p13.2 intercellular adhesion molecule 1 (CD54), human rhinovirus receptor ICAM4 19p13.2-cen intercellular adhesion molecule 4, Landsteiner-Wiener blood group ICAM5 19p13.2 intercellular adhesion molecule 5, telencephalin LOC388505 MGC19604 19p13.2 similar to RIKEN cDNA B230118G17 gene RAVER1 19p13.2 RAVER1 ICAM3 19p13.3-p13.2 intercellular adhesion molecule 3 TYK2 19p13.2 tyrosine kinase 2 CDC37 19p13.2 CDC37 cell division cycle 37 homolog (S. cerevisiae) PDE4A 19p13.2 phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila) KEAP1 19p13.2 kelch-like ECH-associated protein 1 EDG8 19p13.2 endothelial differentiation, sphingolipid G-protein-coupled receptor, 8 AUTL4 19p13.2 AUT-like 4, cysteine endopeptidase (S. cerevisiae) FLJ12949 19p13.2 hypothetical protein FLJ12949 CDKN2D 19p13.2 cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) AP1M2 19p13.2 adaptor-related protein complex 1, mu 2 subunit CTL2 19p13.1 adaptor-related protein complex 1, mu 2 subunit ILF3 19p13 interleukin enhancer binding factor 3, 90kDa QTRT1 19p13.3 queuine tRNA-ribosyltransferase 1 (tRNA-guanine transglycosylase) DNM2 19p13.2 dynamin 2 IL1RL1LG 19p13.2 interleukin 1 receptor-like 1 ligand LOC255809 19p13.2 hypothetical LOC255809 CARM1 19p13.2 hypothetical LOC255809 MGC3262 19p13.2 hypothetical protein MGC3262 LOC90580 19p13.2 hypothetical protein BC011833 SMARCA4 19p13.2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 LDLR 19p13.2 low density lipoprotein receptor (familial hypercholesterolemia) FLJ90806 KIAA1518
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 splicing 3745 90 702 - 2010 21123651
  • NFAR1, NFAR-1 or DRBP76
  • including exon 18 comprising several stop codons
  • stable in the cytoplasmic compartment
  • contain two double-stranded RNA (dsRNA)-binding domains in its C-terminus regions
  • 20 splicing 6058 110 894 ubiquitous 2010 21123651
  • NFAR2, or variant1
  • lacking EXON 18 including EXONS 19, 20
  • migrated between the cytoplasmic and nuclear compartments during the cell cycle, through an additional sequence in the C terminal region leading to nuclear translocation
  • contain two double-stranded RNA (dsRNA)-binding domains in its C-terminus regions, with an extra 192 amino acids encoded by an extra three exons present in its corresponding transcript
  • - - - - 661 - 2000 11167023
    - - - - - - 2000 11167023
    - - 3720 - 702 - 2000 11167023
    20 - 6135 - 898 - 2003 14654356
    ILF3D
    18 - 3302 - 690 - 2003 14654356
  • variant 3, or DRBP76 delta
  • has a distinct C-terminus compared to isoform NFAR2
  • 18 - 3757 - 706 - 2003 14654356
    ILF3E
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immuneactivated B lymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a bipartite nuclear localization signal (NLS)
  • two ds RNA (near the C terminus) and a PRKR binding motif
  • five epitopes for M phase-specific phosphorylation by CDKs
  • a RG2 motif
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Ilf3
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • regulating the transcription at the level of mRNA elongation
  • involved in retaining cellular transcripts in intranuclear foci and can regulate the export of mRNA to the cytoplasm
  • exert influence on mRNA trafficking and the modulation of translation rates and may constitute an innate immune translational surveillance mechanism important in host defense counter measures against virus infection
  • may be involved in the transcription and/or stabilization of selected mRNAs such as IL2 and MYOD
  • regulates inducible IL2 transcription, mRNA stability, and gene expression in T cells
  • potentially inhibits influenza virus replication during the early phase of infection through direct interaction with viral nucleoprotein
  • functional role in co- or post-transcriptional gene regulation may contribute to the neoplastic phenotype
  • constitute a novel, conserved mechanism of host defense used by the cell to detect and impede aberrant translation events
  • ILF3/ILF2 complex is a regulator of DNA damage repair mediated by DNA-dependent protein kinase (DNA-PK), suggesting that structured RNA may modulate this process
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of the nuclear factor of activated T cells, heterodimerizing with ILF2
  • ILF3-ILF2 complex functions as a negative regulator in the microRNA processing pathway
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ILF2
  • SERBP1 and ILF3 were identified as NR5A2 interacting partners
  • like ADARB1, underlying sequences in dsRNA may influence how ILF3 recognizes its target RNAs
  • cell & other
    REGULATION
    activated by PRKR
    induced by interferon inducible
    inhibited by cyclosporin A and FK506
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyimmunodeficiency 
    therapeutic target for the modulation of T cell immune responses
    ANIMAL & CELL MODELS