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FLASH GENE
Symbol ILF2 contributors: mct - updated : 18-08-2011
HGNC name interleukin enhancer binding factor 2, 45kDa
HGNC id 6037
Location 1q21.1      Physical location : 153.634.514 - 153.643.479
Synonym name nuclear factor of activated T cells,45kD
Synonym symbol(s) NF45, MGC8391, PRO3063
DNA
TYPE functioning gene
STRUCTURE 8.97 kb     14 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 1637 43 390 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus   highly
Cardiovascularheart   highly
Digestiveliver   highly
Endocrinepancreas   highly
Nervousbrain   highly
Reproductivemale systemprostate  highly
Respiratorylung   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immuneactivated B lymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
interspecies homolog to murine Ilf2
homolog to Drosophila CG5641
homolog to C.elegans R11H6.5
Homologene
FAMILY
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • binding NFAT and stimulating its ability to enhance gene expression
  • ILF3/ILF2 complex is a regulator of DNA damage repair mediated by DNA-dependent protein kinase (DNA-PK), suggesting that structured RNA may modulate this process
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of Nuclear Factor of Activated T-cells (NF-AT)
  • ILF3-ILF2 complex functions as a negative regulator in the microRNA processing pathway
  • INTERACTION
    DNA binding with NP90 to NF-AT target DNA sequence, binding to antigen receptor response element 2 (ARRE2) in IL2 enhancer
    RNA
    small molecule
    protein
  • NP90/ILF3
  • cell & other
    REGULATION
    inhibited by cyclosporin A and FK506
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS