basic FUNCTION
| play a critical role in the V(D)J recombination during lymphocyte development |
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playing a necessary but not sufficient role for the formation of memory CD8 T cells during viral infection |
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IL7 and IL7R are essential for normal T-cell development and homeostasis |
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IL7R–mediated signaling plays an active role in the T-cell leukemogenic process |
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IL-7R differentially controls development and maturation of thymocyte subpopulations in late developmental stages (pMID: 23267098) |
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activated IL7 receptors embedded in membrane microdomains induce actin-microfilament meshwork formation, anchoring microtubules that grow radially from rafted receptors to the nuclear membrane |
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IL7R Tyr(449) was essential for IL7R signaling in bone marrow B cell development and survival |
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plays critical roles in lymphocyte development and homeostasis |
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importance of IL7R mediated signals for normal human B-cell production |
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IL7/IL7R are essential for normal T-cell development and homeostasis, whereas excessive IL7/IL7Receptor-mediated signaling promotes leukemogenesis |
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induction of IL7R expression on Dendritic cells is critical for Thymic stromal lymphopoietin (TSLP) responsiveness and IL4 can upregulate IL7R on Dendritics cells |
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Il7R-dependent cells are likely required to set up the microenvironments that allow accumulation of thymic Dendritic cells (PMIDS: |
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is essential for leukemia-initiating cell activity of T-cell acute lymphoblastic leukemia |