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Symbol IL7R contributors: mct - updated : 23-03-2020
HGNC name interleukin 7 receptor
HGNC id 6024
Corresponding disease
SCIDTL severe combined immunodeficiency, lacking T lymphocytes
Location 5p13.2      Physical location : 35.856.990 - 35.876.921
Synonym name
  • CD127 antigen
  • interleukin 7 receptor alpha chain
  • Synonym symbol(s) CD127, CDW127, IL-7R-alpha, IL7RA, ILRA
    TYPE functioning gene
    STRUCTURE 22.71 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • methylation of promoter could be a potential target for modifying IL-7-mediated T cell development and survival
  • CpG sites in the IL7R promoter were hypermethylated in Schimke immuno-osseous dysplasia (SIOD) T cells
  • MAPPING cloned Y linked N status provisional
    Physical map
    TARS 5p13.3-p13.2 threonyl-tRNA synthetase LOC389279 5 similar to RPE-spondin LOC391776 5 similar to Probable mitochondrial import receptor subunit TOM40 homolog (Translocase of outer membrane 40 kDa subunit homolog) (Haymaker protein) (p38.5) ADAMTS12 5q35 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12 SALPR 5p15.1-p14 G-protein coupled receptor SALPR MATP 5p13.3 membrane associated transporter protein AMACR 5p13.3-p12 alpha-methylacyl-CoA racemase C1QTNF3 5p13-p12 C1q and tumor necrosis factor related protein 3 LOC389280 5 similar to SMA3 protein LOC389281 5 similar to bA110H4.2 (similar to membrane protein) RAI14 5p13.3-p13.2 retinoic acid induced 14 FLJ25439 5p13.3 hypothetical protein FLJ25439 RAD1 5p13.3-p13.2 RAD1 homolog (S. pombe) BRIX 5p13.3 BRIX LOC134218 5p13.3 hypothetical protein LOC134218 AGXT2 5p13 alanine-glyoxylate aminotransferase 2 PRLR 5p14-p13.3 prolactin receptor LOC389282 5 similar to RIKEN cDNA C230086A09 gene FLJ23577 5p13.2 hypothetical protein FLJ23577 IL7R 5p13 interleukin 7 receptor MGC26610 5p13.2 hypothetical protein MGC26610 FLJ34658 5p13.2 hypothetical protein FLJ34658 LOC167127 5p13.2 hypothetical protein LOC167127 DKFZp434H2226 5p13.2 hypothetical protein DKFZp434H2226 SKP2 5p13 S-phase kinase-associated protein 2 (p45) FLJ30596 5p13.2 hypothetical protein FLJ30596 FLJ25422 5p13.2 hypothetical protein FLJ25422 SLC1A3 5p13 solute carrier family 1 (glial high affinity glutamate transporter), member 3 LOC345513 5p13.2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) IDN3 5p13.2 IDN3 protein LOC391777 5 similar to ribosomal protein S4, X-linked FLJ13231 5p13.2 hypothetical protein FLJ13231 LOC389283 5 LOC389283 OFD1P1 5p13 oral-facial-digital syndrome 1, pseudogene 1 NUP155 5p13 nucleoporin 155kDa FLJ10233 5p13.2 hypothetical protein FLJ10233 GDNF 5p13-p12 glial cell derived neurotrophic factor FLJ39155 5p13.2 hypothetical protein FLJ39155
    TRANSCRIPTS type messenger
    text with an alternatively spliced secreted form
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 4584 49.5 459 - 2019 30377306
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Lymphoid/Immunelymph node   highly
     spleen   highly
     thymus   highly
    cell lineage
    cell lines
    at STAGE
  • a ligand binding domain
  • the cytokine receptor-like domain containing cysteine residues
  • a WSXWS motif
  • type I cytokine receptor family
  • type 4 subfamily
  • CATEGORY signaling cytokine , receptor
        plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • play a critical role in the V(D)J recombination during lymphocyte development
  • playing a necessary but not sufficient role for the formation of memory CD8 T cells during viral infection
  • IL7 and IL7R are essential for normal T-cell development and homeostasis
  • IL7R–mediated signaling plays an active role in the T-cell leukemogenic process
  • IL-7R differentially controls development and maturation of thymocyte subpopulations in late developmental stages (pMID: 23267098)
  • activated IL7 receptors embedded in membrane microdomains induce actin-microfilament meshwork formation, anchoring microtubules that grow radially from rafted receptors to the nuclear membrane
  • IL7R Tyr(449) was essential for IL7R signaling in bone marrow B cell development and survival
  • plays critical roles in lymphocyte development and homeostasis
  • importance of IL7R mediated signals for normal human B-cell production
  • IL7/IL7R are essential for normal T-cell development and homeostasis, whereas excessive IL7/IL7Receptor-mediated signaling promotes leukemogenesis
  • induction of IL7R expression on Dendritic cells is critical for Thymic stromal lymphopoietin (TSLP) responsiveness and IL4 can upregulate IL7R on Dendritics cells
  • Il7R-dependent cells are likely required to set up the microenvironments that allow accumulation of thymic Dendritic cells (PMIDS:
  • is essential for leukemia-initiating cell activity of T-cell acute lymphoblastic leukemia
  • IL7R signaling pathway may play a role in the autoimmune process in Neuromyelitis optica (NMO) (pMID: 30248528)
  • a component
  • heterodimeric complex consisting of the IL-7Ralpha and common interleukin-2 receptor gamma (IL-2Rgamma(c)) chains
    small molecule
  • EFNB1 and EFNB2 interacted physically with IL7R
  • novel function of EFNB1 and EFNB2 in stabilizing IL7R expression at the post-translational level
  • IL7R is a transcriptional target of NOTCH1
  • CPSF1 interaction with intronic IL7R pre-mRNA interferes likely with spliceosome binding to the exon 6 5' splice site
  • soluble IL7R potentiates IL7 bioactivity
  • GATA3 plays parallel roles in regulating the development and functions of CD4(+) T cells and IL7R Innate lymphoid cells (ILCs)
  • ZFAT is required for peripheral T-cell homeostasis through IL7R expression by controlling the FOXO1 protein
  • SH2B3 suppresses IL7R/JAK/STAT signaling to restrict pro-/pre-B progenitor expansion and leukemia development
  • casein kinase 2 is a major player in the effects of IL7 and IL7R in T-cell acute lymphoblastic leukemia
  • IL7R function is essential for NOTCH1-induced T-cell leukemogenesis
  • cell & other
    Other an enhancer of the IL7R controls IL7R expression and maintenance of peripheral T cells
    corresponding disease(s) SCIDTL
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    on all antigen-specific effector CD8 T cells during viral infection
    tumoral somatic mutation     gain of function
    in T-cell acute lymphoblastic leukemia (T-ALL)
    constitutional somatic mutation     loss of function
    associated to immunodeficiency
    constitutional     --low  
    in Neuromyelitis optica (NMO)
  • to multiple sclerosis (MS)
  • to Ulcerative colitis
  • Variant & Polymorphism SNP , other
  • SNP, rs6897932, located within the alternatively spliced exon 6 of IL7R, significantly associated with multiple sclerosis
  • significant association between the IL7R T244I polymorphism and MS
  • polymorphisms in IL7R, which had the largest coefficient, are associated with Ulcerative colitis susceptibility (
  • Candidate gene
    Therapy target
  • useful therapeutic target in primary progressive course from the onset (PPMS)form of multiple sclerosis
  • expression of functional IL7R on epithelial tumour cells may represent a potential target for receptor-directed therapy