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FLASH GENE
Symbol IL7 contributors: mct/npt - updated : 09-04-2016
HGNC name interleukin 7
HGNC id 6023
Location 8q21.12      Physical location : 79.645.005 - 79.717.758
Synonym name IL7 nirs variant 6
Synonym symbol(s) EVI51, IL-7
DNA
TYPE functioning gene
STRUCTURE 72.75 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2116 - 177 - -
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrineneuroendocrinepituitary  highly
Lymphoid/Immunelymph node   highly
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Il7
Homologene
FAMILY
  • interleukin family (IL7/IL9 family)
    • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • hematopoietic growth factor, stimulating the proliferation of lymphoid progenitor cells
  • plays an important role in the normal development and maintenance of the immune system
  • produced by some human tumour cells and involved in tumour development and progression
  • with TSLP, use different mechanisms to regulate human CD4(+) T cell homeostasis (Lu 2009)
  • IL7 plays vital roles in thymocyte development, T cell homeostasis, and the survival of these cells
  • IL7- and IL15-mediated TCR sensitization enables T cell responses to self-antigens
  • IL7 is the main homeostatic regulator of CD4 T-lymphocytes (helper) at both central and peripheral levels
  • TNFRSF4 and IL7 play synergistic, but distinct roles in the homeostatic proliferation of CD4(+) effector memory T (TEM) cells
  • IL7/IL7R are essential for normal T-cell development and homeostasis, whereas excessive IL7/IL7Receptor-mediated signaling promotes leukemogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • effects are mediated via its receptor, IL7R
  • soluble IL7R potentiates IL7 bioactivity
  • IFNA1 mediates inhibition of IL7- or IL2-induced T cell proliferation
  • casein kinase 2 is a major player in the effects of IL7 and IL7R in T-cell acute lymphoblastic leukemia
  • IL7 stimulation induced the phosphorylation of the proteins STIP1, ATIC and HNRNPH1, involved in pathways related to survival, proliferation and gene expression, respectively, and increased the phosphorylation of CRKL
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS