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FLASH GENE
Symbol IL6ST contributors: mct/ - updated : 13-09-2017
HGNC name interleukin 6 signal transducer (gp130, oncostatin M receptor)
HGNC id 6021
Location 5q11.2      Physical location : 55.230.937 - 55.290.821
Synonym name
  • oncostatin M receptor
  • gp130 transducer chain
  • interleukin receptor beta chain
  • membrane glycoprotein gp130
  • IL-6 receptor subunit beta2
  • CD130 antigen
    • Synonym symbol(s) GP130, IL6ST1, CD130, CDw130, IL6R-beta, DKFZp564F053
    DNA
    TYPE functioning gene
    STRUCTURE 59.90 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    text with an alternatively spliced secreted form
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 9071 - 918 - 2007 17436251
    16 - 8988 - 329 - 2007 17436251
    16 - 8888 - 857 - 2000 10675624
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Hearing/Equilibriumearinnercochlea highly
    Nervousnerve   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cytokine binding domain (CBD)
  • two fibronectin III domains linked by a proline-rich sequence: N-terminal fibronectin III domain of the CBD characterized by two conserved disulfide bridges
  • C-terminal fibronectin III domain of the CBD with a conserved WSXWS motif
  • intracellula
  • N-glycosylation of the extracellular domains D1-D3 has been shown to be dispensable for binding of the IL6ST ligand IL-6 and its cognate receptor
  • box 1 and box 2-like motifs conserved in cytokine receptors
    • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • class I hematopoietin receptor family
    • CATEGORY signaling hormone cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein, cholesterol enriched membrane microdomains (rafts)
    basic FUNCTION
  • interleukin 6, signal transducer (GP130), needed for IL6R activity and signal transduction of the IL-6 related cytokines mediated by JAK kinases
  • IL6 and IL6ST may enhance pain not only indirectly through their proinflammatory actions but also through a direct action on nociceptors
  • its activation in photoreceptors had potentially a general protective role independent of whether stress was caused by light or genetic mutations
  • shared signal-transducing receptor subunit for the large and important family of interleukin 6-like cytokines
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • common transducing component for IL6RA, LIFR, CNTFR, CSF3R (see symbols)
  • component of microdomains rafts
  • heterodimerizing with OSMR
  • quaternary cytokine receptor complex consisting of IL6ST, LIFR, the cytokine Ciliary Neurotrophic Factor (CNTF), and its alpha receptor (CNTFRA)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • shared receptor for at least nine cytokines and can signal either as a homodimer or as a heterodimer with Leukemia Inhibitory Factor Receptor (LIFR)
  • MTRNR2L1 inhibits neuronal cell death and dysfunction by binding to a novel IL6-receptor-related receptor(s) on the cell surface involving CNTFR, IL27RA, and IL6ST
  • interacting with Sortilin
  • excessive CXCL1 expression in IL6ST-deficient endothelial cells augments neutrophil adhesion but hinders migration, most likely by disrupting chemotactic gradients
  • TRAF5 binds to the signal-transducing receptor IL6ST through the C-terminal TRAF domain and inhibits Th17 development mediated by IL6
    • cell & other
    REGULATION
    Other regulated by N-linked glycosylation that is required for the stability but not the signal-transducing function
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS