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FLASH GENE
Symbol IL6R contributors: mct - updated : 13-09-2017
HGNC name interleukin 6 receptor
HGNC id 6019
Location 1q21      Physical location : 154.377.668 - 154.440.188
Synonym name CD126 antigen
Synonym symbol(s) CD126, IL-6R-1, IL-6R-alpha, IL6RA, MGC104991
DNA
TYPE functioning gene
STRUCTURE 62.00 kb     10 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 4176 - 468 - Ruggeri
- - 4082 - 365 expressed in peripheral blood mononuclear cells and weakly found in urine and serum Ruggeri
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
Homologene
FAMILY
CATEGORY signaling cytokine , receptor
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
    intracellular
intracellular,nucleus
basic FUNCTION involved in the regulation of the immune response, acute-phase reactions and hematopoiesis
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
  • heterodimerizing with IL6ST
  • hexamer of two molecules each of IL6, IL6R and IL6ST
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TRAF5 is a negative regulator of the IL6R signaling pathway that limits the induction of proinflammatory CD4(+) T cells that require IL6 for their development
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS