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FLASH GENE
Symbol IL5RA contributors: mct - updated : 14-05-2008
HGNC name interleukin 5 receptor, alpha
HGNC id 6017
Location 3p26-p24      Physical location : 3.111.400 - 3.152.058
Synonym name CD125 antigen
Synonym symbol(s) CD125, CDw125, HSIL5R3, IL5R, MGC26560
DNA
TYPE functioning gene
STRUCTURE 40.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
CCR2 3p21.31 chemokine (C-C motif) receptor 2 CCR5 3p21.31 chemokine (C-C motif) receptor 5 CCRL2 3p21.32-p21.31 chemokine (C-C motif) receptor-like 2 CHL1 3p26 cell adhesion molecule with homology to L1CAM (close homolog of L1) LOC391503 3 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) CNTN6 3p26-p25 contactin 6 LOC391504 3 similar to 60S ribosomal protein L23a LOC391505 3 similar to 60S ribosomal protein L21 CNTN4 3p26.2 contactin 4 IL5RA 3p26-p25 interleukin 5 receptor, alpha TRNT1 3p25.1 tRNA nucleotidyl transferase, CCA-adding, 1 LOC51185 3p26.2 protein x 0001 LRRN1 3p26.2 leucine rich repeat neuronal 1 SETMAR 3p26.1 SET domain and mariner transposase fusion gene SUMF1 3p26.2 SET domain and mariner transposase fusion gene MRPS10P2 3p26 mitochondrial ribosomal protein S10 pseudogene 2 ITPR1 3p26-p25 inositol 1,4,5-triphosphate receptor, type 1 BHLHB2 3p26.1-p25.3 basic helix-loop-helix domain containing, class B, 2 LOC391506 3 similar to autoantigen NOR-90 FLJ10702 EDEM1 3p26.1 ER degradation enhancer, mannosidase alpha-like 1 MRPS35P1 3p25.3 mitochondrial ribosomal protein S35 pseudogene 1 MRPS36P1 3p25.3 mitochondrial ribosomal protein S36 pseudogene GRM7 3p26.1-p25.2 glutamate receptor, metabotropic 7 LOC389092 3 LOC389092 LMCD1 3p26-p24 LIM and cysteine-rich domains 1 LOH3CR2A 3 loss of heterozygosity, 3, chromosomal region 2, gene A LOC51066 3p25.3 fls485 LOC391507 3 similar to seven transmembrane helix receptor CAV3 3p25 caveolin 3 OXTR 3p25 oxytocin receptor RAD18 3p25-p24 RAD18 homolog (S. cerevisiae)
RNA
TRANSCRIPTS type messenger
text with an alternatively spliced secreted form
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2367 - 420 - Liu (2008)
- - 2024 - 333 - Liu (2008)
12 - 2299 - 420 - Liu (2008)
- - 1694 - 335 - Liu (2008)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach    
Respiratoryrespiratory tracttrachea   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three FBN-like motifs
  • two cytokine receptor-like domains conserved WSXWS motif(s)
  • a cytoplasmic tail with a proline cluster
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • has a role for controlling eosinophils in the peripheral blood
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterodimerizing with CSF2RB
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to sporadic IgA nephropathy
  • to asthma development, especially in atopic populations
  • Variant & Polymorphism SNP increasing the risk of asthma development, especially in atopic populations
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS