protein
| activating STAT6 |
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regulating CCR5 and CD4 expression and HIV1 replication in macrophages and microglia |
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MINA, is an IL4 repressor, controling T helper type 2 bias |
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IL4, IL9, IL13 may increase CLCA1 expression in cystic fibrosis but may not have a significant effect on mucus expression |
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CCL26 is a functional ligand for CCR3 and abundantly produced by IL4-/IL13-stimulated vascular endothelial cells |
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novel role of IL4/IL13-induced DUOX1 expression in making a positive feedback loop for IL4/IL13 signaling in keratinocytes |
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IL4 inhibits osteoclast formation by inhibiting TNFSF11 induction of NFATC1 via STAT6 as an early event, in addition to its suppression of other signaling pathways |
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IRF4 activates IL2 and IL4 promoters in cooperation with REL |
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role of posttranslational modification of MAF in IL4 production and Th cell-mediated autoimmune diseases |
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IL4 downregulated in a STAT6-dependent manner the memory-specific expression of KLRK1, thereby increasing the activation threshold of memory CD8 T cells |
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thyroid hydrogen peroxide production is enhanced by the Th2 cytokines, IL4 and IL13, through increased expression of the DUOX2 and its maturation factor DUOXA2 |
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while IL4 inhibits and activates different sets of lysosomal genes, STAT6 mediates only the activating effects of IL4, by promoting increased expression and by neutralizing undefined inhibitory signals induced by IL4 |
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ICOS costimulation-dependent translational control may ensure targeted delivery of IL4 to cognate B cells during T-B collaborations in the germinal center |
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key role for KLF13 in the expression of IL4 in CD4(+) T cells |
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KLF13 cooperates with MAF to regulate IL4 expression in CD4+ T cells |
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IL4 was able to inhibit BCL2L11 upregulation and prevent cell death, and downmodulation of BCL2L11 by IL4 occurred in a posttranscriptional manner |
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IL4 increases the binding of STAT6 to its response elements in the IL19 promoter |
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IL4 is essential for the production of IL31, whereas TGFB1 significantly suppresses IL31 expression at the mRNA and protein levels |
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IL4 cooperates likely with IL5 to promote eosinophil differentiation |
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IL4 and IL13, are critical factors for the induction of CCL26 in the pancreas |
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IL4 and IL21 cooperate to induce the high BCL6 protein level required for germinal center formation |
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DUOX1 regulates primary B cell function under the influence of IL4 through BCR-mediated generation of hydrogen peroxide |