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FLASH GENE
Symbol IL3RA contributors: np - updated : 03-02-2011
HGNC name interleukin 3 receptor, alpha (low affinity)
HGNC id 6012
Location Xp22.33 or Yp11.32      Physical location : 1.405.508 - 1.501.581
Synonym name
  • CD123 antigen
  • interleukin 3 receptor
    • Synonym symbol(s) IL3R, CD123, IL3RX, IL3RY, IL3RAY, hIL-3Ra, MGC34174
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 46.07 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter- [CSF2RA - IL3RA - SLC25A6 ] - PABX - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1726 43 378 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Visualeyeuveachoroid  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Epithelialbarrier/liningretinal pigment epithelium (RPE)  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage acute myeloid and lymphoid leukemia B cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , dimer
    HOMOLOGY
    intraspecies homolog to CSF2RAX, highly
    Homologene
    FAMILY
  • type I cytokine receptor family
  • type 5 subfamily
    • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • low affinity receptor to interleukin 3
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • heterodimerizing with CSF2B
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS