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FLASH GENE
Symbol IL36A contributors: mct - updated : 24-11-2017
HGNC name interleukin 1 family, member 6 (epsilon)
HGNC id 15562
Location 2q13      Physical location : -
Synonym name
  • interleukin 1, epsilon
  • IL-1F6 (FIL-1-epsilon)
  • IL-1 epsilon
  • Synonym symbol(s) FIL1E, IL1(epsilon), FIL1E, IL-1F6, MGC129552, MGC129553, IL1F6
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 2.17 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 477 - 158 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve stranded beta trefoil structure
  • HOMOLOGY
    intraspecies homolog to FIL1H
    Homologene
    FAMILY
  • IL-1 family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IL36A, IL36B, IL36G cytokines actively propagate skin inflammation via the activation of keratinocytes, APC, and, indirectly, T cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS