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FLASH GENE
Symbol IL34 contributors: mct - updated : 24-03-2012
HGNC name interleukin 34
HGNC id 28529
Location 16q22.1      Physical location : 70.613.797 - 70.694.585
Synonym name
  • chromosome 16 open reading frame 77
  • hypothetical protein LOC146433
  • Synonym symbol(s) MGC34647, IL-34, C16orf77
    DNA
    TYPE functioning gene
    STRUCTURE 80.79 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1779 27 242 - 2010 20504948
    7 - 1796 - 242 - 2010 20504948
    7 - 1793 - 241 - 2010 20504948
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • functional overlap but differential expression of CSF1 and IL34 in their CSF1 receptor-mediated regulation of myeloid cells
  • important player in osteoclastogenesis and thus may have a role in bone diseases
  • cytokine implicated in macrophage differentiation and osteoclastogenesis
  • as a downstream effector of TNF and IL1B, may contribute to inflammation and bone erosions in rheumatoid arthritis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a ligand of CSF1R
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS