| basic FUNCTION
| may be involved in lung macrophage activation in clinical asthma  |
|
CASP1, CASP8, and calpain are dispensable for IL33 release by macrophages |
|
host-protective against helminth infection and reduces atherosclerosis by promoting TH2-type immune responses |
|
may function as an endogenous danger signal or alarmin, similar to IL1A and HMGB1 |
|
with its receptor, IL1RL1, may play important roles in eosinophil-mediated inflammation |
|
prevents cardiomyocyte apoptosis and improves cardiac function and survival after MI through IL1RL1 signaling |
|
have an important role in sensing damage in various infectious and inflammatory diseases |
|
may be an important cytokine in the initiation and perpetuation of inflammation |
|
crucial amplifier of mucosal and systemic innate, rather than acquired, immune responses |
|
seems to play a critical role in various types of innate-type inflammation in the lung and gut, whereas it is dispensable for acquired immune responses |
|
crucial as an alarmin for innate-type, but not acquired-type, tissue injury-related inflammatory responses such as LPS-induced endotoxin shock |
|
nuclear IL33 sequesters nuclear NFKB and reduces NFKB-triggered gene expression to dampen proinflammatory signaling |
|
proteolytic processing may play an important role in the regulation of IL33 activity during inflammation |
|
in the nucleus of endothelial cells participates in inflammatory reactions as a transcriptional regulator of RELA |
|
dual-function molecule that regulates gene expression in nuclei and, as a cytokine, conveys proinflammatory signals from outside of cells via its specific receptor IL1RL1 |
|
IL33/IL1RL1 signaling plays an important role in regulating IL33 induced inflammatory responses in ocular surface |
|
may play a pivotal role in maintenance of cutaneous homeostasis and acceleration of normal wound healing |
|
predominantly induces type 2 immune responses and thus is protective against atherosclerosis and nematode infections but contributes to allergic airway inflammation |
|
IL33, may induce inflammatory molecule release from the glial cells and may play an important role in the pathogenesis of Alzheimer disease |
|
acts as an immunoadjuvant to enhance antigen-specific tumor immunity |
|
contributes to disease processes in association with Th1 and Th2 phenotypes |
|
cell-intrinsic role for the IL33/IL1RL1 axis in the regulation of apoptosis in mast cellls, identifying thereby a previously unappreciated pathway supporting expansion of the mast cellls population with inflammation |
|
IL33/IL1RL1 axis plays an essential role in the development of visceral adipose tissue Treg (VAT-Treg) cells |
|
IL33 and IL1RL1 function as a developmental switch to license thermogenesis during the perinatal period |
