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FLASH GENE
Symbol IL33 contributors: mct/npt/pgu - updated : 14-04-2010
HGNC name interleukin 33
HGNC id 16028
Location 9p24.1      Physical location : 6.241.677 - 6.257.982
Synonym name
  • DVS27-related protein
  • chromosome 9 open reading frame 26 (NF-HEV)
  • interleukin-1 family member 11
  • nuclear factor from high endothelial venules
    • Synonym symbol(s) DVS27, NFEHEV, DKFZp586H0523, C9orf26, IL1F11, NFHEV, RP11-575C20.2, IL-33
    DNA
    TYPE functioning gene
    STRUCTURE 16.31 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2644 30 270 - 2007 17185418
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvesselaorta   
    Digestiveliver    
    Nervousbrain    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial
    not specificadipocyte
    not specificfibroblast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    isoforms Precursor synthesized as a 30-kDa precursor (pro-IL-33). Pro-IL-33 is cleaved by caspase-1 into an 18-kDa mature form (mature IL-33)
    HOMOLOGY
    Homologene
    FAMILY
  • IL-1 family
    • CATEGORY secretory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus
    text in the absence of pro-inflammatory stimuli, localizes to the nucleus
    basic FUNCTION
  • may be involved in lung macrophage activation in clinical asthma
  • CASP1, CASP8, and calpain are dispensable for IL33 release by macrophages
  • host-protective against helminth infection and reduces atherosclerosis by promoting TH2-type immune responses
  • may function as an endogenous danger signal or alarmin, similar to IL1A and HMGB1
  • with its receptor, IL1RL1, may play important roles in eosinophil-mediated inflammation
  • prevents cardiomyocyte apoptosis and improves cardiac function and survival after MI through IL1RL1 signaling
  • have an important role in sensing damage in various infectious and inflammatory diseases
  • may be an important cytokine in the initiation and perpetuation of inflammation
  • crucial amplifier of mucosal and systemic innate, rather than acquired, immune responses
  • seems to play a critical role in various types of innate-type inflammation in the lung and gut, whereas it is dispensable for acquired immune responses
  • crucial as an alarmin for innate-type, but not acquired-type, tissue injury-related inflammatory responses such as LPS-induced endotoxin shock
  • proteolytic processing may play an important role in the regulation of IL33 activity during inflammation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for the then orphan receptor IL1RL1
  • processed into mature bioactive forms by neutrophil elastase and cathepsin G
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    more abundantly expressed in the lung epithelial cells of asthma patients than those from healthy controls
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • could be a new target for therapeutic intervention across a range of diseases
    • SystemTypeDisorderPubmed
    immunologyinflammatory 
    may provide new therapeutic targets for controlling mucosal eosinophilic inflammation
    cardiovascularaquiredheart failure
    IL33/IL1RL1 not only represents a promising cardiovascular biomarker but also a novel mechanism of intramyocardial fibroblast-cardiomyocyte communication that may prove to be a therapeutic target for the prevention of heart failure
    ANIMAL & CELL MODELS