basic FUNCTION
| may be involved in lung macrophage activation in clinical asthma  |
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CASP1, CASP8, and calpain are dispensable for IL33 release by macrophages  |
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host-protective against helminth infection and reduces atherosclerosis by promoting TH2-type immune responses  |
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may function as an endogenous danger signal or alarmin, similar to IL1A and HMGB1 |
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with its receptor, IL1RL1, may play important roles in eosinophil-mediated inflammation  |
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prevents cardiomyocyte apoptosis and improves cardiac function and survival after MI through IL1RL1 signaling |
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have an important role in sensing damage in various infectious and inflammatory diseases  |
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may be an important cytokine in the initiation and perpetuation of inflammation  |
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crucial amplifier of mucosal and systemic innate, rather than acquired, immune responses  |
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seems to play a critical role in various types of innate-type inflammation in the lung and gut, whereas it is dispensable for acquired immune responses  |
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crucial as an alarmin for innate-type, but not acquired-type, tissue injury-related inflammatory responses such as LPS-induced endotoxin shock  |
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nuclear IL33 sequesters nuclear NFKB and reduces NFKB-triggered gene expression to dampen proinflammatory signaling  |
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proteolytic processing may play an important role in the regulation of IL33 activity during inflammation  |
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in the nucleus of endothelial cells participates in inflammatory reactions as a transcriptional regulator of RELA  |
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dual-function molecule that regulates gene expression in nuclei and, as a cytokine, conveys proinflammatory signals from outside of cells via its specific receptor IL1RL1 |
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IL33/IL1RL1 signaling plays an important role in regulating IL33 induced inflammatory responses in ocular surface  |
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may play a pivotal role in maintenance of cutaneous homeostasis and acceleration of normal wound healing  |
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predominantly induces type 2 immune responses and thus is protective against atherosclerosis and nematode infections but contributes to allergic airway inflammation  |
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IL33, may induce inflammatory molecule release from the glial cells and may play an important role in the pathogenesis of Alzheimer disease  |
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acts as an immunoadjuvant to enhance antigen-specific tumor immunity  |
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contributes to disease processes in association with Th1 and Th2 phenotypes  |
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cell-intrinsic role for the IL33/IL1RL1 axis in the regulation of apoptosis in mast cellls, identifying thereby a previously unappreciated pathway supporting expansion of the mast cellls population with inflammation  |
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IL33/IL1RL1 axis plays an essential role in the development of visceral adipose tissue Treg (VAT-Treg) cells  |
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IL33 and IL1RL1 function as a developmental switch to license thermogenesis during the perinatal period  |