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FLASH GENE
Symbol IL32 contributors: mct - updated : 13-05-2008
HGNC name interleukin 32
HGNC id 16830
Location 16p13.3      Physical location : 3.115.312 - 3.119.667
Synonym name
  • natural killer cell group 4
  • natural killer cell transcript 4
  • tumor necrosis factor alpha-inducing factor
  • Synonym symbol(s) IL-32alpha, IL-32beta, IL-32delta, IL-32gamma, NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd
    DNA
    TYPE functioning gene
    STRUCTURE 4.00 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map see MEFV
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1157 21.6 188 - Raymond, Netea (2008)
  • isoform B or IL-32beta
  • 8 - 919 14.7 131 - Raymond, Netea (2008)
  • lacking an alternate exon in the 5'UTR and containing an alternate intron within the last exon of the coding region
  • nearly without activity in inducing macrophage differentiation
  • 6 - 897 19.2 168 - Raymond, Netea (2008)
  • lacking an alternate exon in the 5'UTR and an in-frame exon in the coding region
  • 20-50 times more active in inducing monocyte differentiation than the IL-32 alpha isoform with two coding exon deletions
  • 6 - 892 19.2 168 - Raymond, Netea (2008)
  • different in the 5'UTR and lacking an alternate in-frame exon in the coding region
  • isoform C
  • 5 - 880 20.6 179 - Raymond, Netea (2008)
  • lacking two alternate in-frame exons in the 5'UTR and an alternate in-frame exon in the coding region
  • isoform D
  • 7 splicing 1093 21.6 188 - Raymond, Netea (2008)
  • containing an alternate in-frame splice site in the 5'UTR
  • isoform B
  • 7 - 1090 21.6 188 - Raymond, Netea (2008)
  • lacking an alternate exon in the 5'UTR
  • isoform B
  • 7 - 956 21.6 188 - Raymond, Netea (2008)
  • multiples differences in the 5'UTR
  • isoform B
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveesophagus   highly
     stomach   highly
    Urinarykidney   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immuneactivated B lymphocyte
    cell lineage
    cell lines
    fluid/secretion secreted protein
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three potential N-myristoylation sites
  • one N-glycosylation site
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • potentially involved in cell adhesion
  • may play a role in lymphocyte activation
  • inducing the production of TNFalpha from macrophage cells
  • playing a role in the pathophysiology of clonal myeloid diseases
  • not only contributes to host responses through the induction of proinflammatory cytokines but also directly affects specific immunity by differentiating monocytes into macrophage-like cells
  • may be playing a role in inflammatory bowel diseases
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in rheumatoid arthritis synovial tissue
    tumoral     --other  
    dysregulation in myelodysplastic syndrome (MDS) and myeloproliferative disorder
    Susceptibility to rheumatoid arthritis
    Variant & Polymorphism SNP
    Candidate gene
    Marker
    Therapy target therapeutic targets for patients with myelodysplastic syndrome (MDS) and myeloproliferative disorder
    ANIMAL & CELL MODELS