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FLASH GENE
Symbol IL31 contributors: mct - updated : 08-09-2015
HGNC name interleukin 31
HGNC id 19372
Location 12q24.31      Physical location : 122.656.577 - 122.658.746
Synonym symbol(s) IL-31
DNA
TYPE functioning gene
STRUCTURE 10.93 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 904 - 164 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 intestinesmall intestine   
Lymphoid/Immunethymus    
Reproductivemale systemtestis   
Respiratoryrespiratory tracttrachea   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
Skin/Tegumentkeratinocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
isoforms Precursor producing a 141 aa mature protein
HOMOLOGY
Homologene
FAMILY IL6 protein family
CATEGORY signaling cytokine
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma
  • activating STAT1, STAT3 and STAT5
  • might contribute to the development of AD-induced skin inflammation and pruritus
  • cytokine involved in pruritic skin diseases including atopic dermatitis (AD) and chronic spontaneous urticaria
  • functional role of I31 in in human primary keratinocytes (HPKs)
  • is a key mediator of itching in atopic dermatitis (AD) and is preferentially produced by activated CD4(+) T cells and Th2 cells
  • OSM and interleukin-31 (IL31) are two cytokines belonging to the IL6 family which share a common signaling receptor subunit, OSMR
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
  • IL31 signaling may be a contributing factor in the persistence and exacerbation of atopic dermatitis (AD), skin lesions
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • T-cell cytokine acting through a heterodimeric receptor composed of IL31RA and OSMR
  • IL4 is essential for the production of IL31, whereas TGFB1 significantly suppresses IL31 expression at the mRNA and protein levels
  • NFATC2 and JUNB cooperatively regulate IL31 gene expression in CD4+ T cells in health and disease
  • cell & other
    REGULATION
    Other expression is associated with cutaneous lymphocyte antigen (CLA)-positive T cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    IL-31 was significantly overexpressed in pruritic atopic compared with nonpruritic psoriatic skin inflammation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • alopecia, severe pruritis, skin thickening, and conjunctivitis, but no internal organ changes, in transgenic mice overexpressing mouse Il31
  • Treatment of Rag1 -/- mice with exogenous Il31 demonstrated that the alopecia, but not the pruritis, was lymphocyte dependent