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FLASH GENE
Symbol IL2RB contributors: mct - updated : 22-02-2008
HGNC name interleukin 2 receptor, beta
HGNC id 6009
Location 22q13.1      Physical location : 37.521.879 - 37.545.962
Synonym name CD122 antigen
Synonym symbol(s) CD122, P70-75
DNA
TYPE functioning gene
STRUCTURE 24.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Physical map
TXN2 22q13.1 thioredoxin 2 FLJ23322 22q13.1 hypothetical protein FLJ23322 EIF3S7 22q13.1 eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa CACNG2 22q13.1 calcium channel, voltage-dependent, gamma subunit 2 RABL4 22q13.1 RAB, member of RAS oncogene family-like 4 PVALB 22q13.1 parvalbumin NCF4 22q13.1 neutrophil cytosolic factor 4, 40kDa CSF2RB 22q13.1 colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) CSF2RB2 22q13.1 colony stimulating factor 2 receptor, beta, 2 MGC35206 22q13.1 hypothetical protein MGC35206 TST 22q13.1 thiosulfate sulfurtransferase (rhodanese) MPST 22q13.1 mercaptopyruvate sulfurtransferase FLJ12242 22q13.1 hypothetical protein FLJ12242 TMPRSS6 22q13.1 transmembrane serine protease 6 IL2RB 22q13.1 interleukin 2 receptor, beta C1QTNF6 22q13.1 C1q and tumor necrosis factor related protein 6 SSTR3 22q13.1 somatostatin receptor 3 RAC2 22q13.1 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) PSCD4 22q13.1 pleckstrin homology, Sec7 and coiled-coil domains 4 KIAA1904 22q13.1 KIAA1904 protein MFNG 22q13.1 manic fringe homolog (Drosophila) CARD10 22q13 caspase recruitment domain family, member 10 CDC42EP1 22q13.1 CDC42 effector protein (Rho GTPase binding) 1 LGALS2 22q13.1 lectin, galactoside-binding, soluble, 2 (galectin 2) GGA1 22q13.31 golgi associated, gamma adaptin ear containing, ARF binding protein 1 SH3BP1 22q13.1 SH3-domain binding protein 1 PLP
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
Reproductivefemale systemplacenta  highly
Respiratoryrespiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two cytokine receptor-like domains each with a pair of cysteines
  • a conserved WSXWS motif necessary for proper protein folding
  • a large cytoplasmic tail containing a motif of 8 residues, targeting the normally recycling receptor toward degradation
  • a box 1 motif required for JAK interaction and/or activation
  • a fibronectin type-III domain
  • mono polymer dimer
    HOMOLOGY
    Homologene
    FAMILY type I cytokine receptor family, type 4 subfamily
    CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    text type I transmembrane protein
    basic FUNCTION involved in receptor mediated endocytosis and
    transduces the mitogenic signals of IL2
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component non-covalent dimer of an alpha and a beta chains
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting wirh HGS that mediates endosomal sorting of the interleukin-2 receptor beta-chain
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to endometriosis
  • to autism spectrum disorder
  • to rheumatoid arthritis
  • Variant & Polymorphism other polymorphism incresing the risk of rheumatoid arthritis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS