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FLASH GENE
Symbol IL27RA contributors: mct/pgu - updated : 04-12-2009
HGNC name interleukin 27 receptor, alpha
HGNC id 17290
Location 19p13.12      Physical location : 14.142.261 - 14.164.025
Synonym name
  • T-cell cytokine receptor type 1
  • type I T-cell cytokine receptor
  • protein CRL1
  • Synonym symbol(s) CRL1, IL27R, TCCR, WSX1, zcytor1, IL-27R, IL-27R-alpha
    DNA
    TYPE functioning gene
    STRUCTURE 21.76 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3258 - 636 - 1998 9600072
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  predominantly
     stomach   highly
    Lymphoid/Immunelymph node   highly
     spleen   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Blood/Hematopoieticprogenitor cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three fibronectin type-III domains
  • a box 1 motif, required for JAK interaction and/or activation
  • a WSXWS motif, necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding
  • seven potential N-glycosylation sites in its extracellular domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Il27ra
    Homologene
    FAMILY
  • type I cytokine receptor family
  • type 2 subfamily
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • acting as a receptor for IL27
  • required IL6ST/gp130 to mediate signal transduction in response to IL27 (through STAT3 and STAT1)
  • involved in the regulation of Th1-type immune responses
  • also appearing to be involved in innate defense mechanisms
  • can trigger signaling in T cells, B cells, and myeloid cells
  • possesses hematopoietic cell-transforming properties, can enhance activation of JAK2 and may be involved in myeloproliferative disorders
  • both CNTFR and IL27RA may be involved in MTRNR2L1 binding to cells
  • highly expressed in epithelial tumor cells where it inhibits tumor growth by enhancing natural killer cytolytic activity
  • soluble IL27RA may play important immunoregulatory functions under normal and pathological conditions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • complexing with IL6ST and CNTFR to form the IL27 receptor
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • a soluble isoform also interacts with IL6ST and CNTFR and forms an alternative functional humanin (anti-Alzheimer's disease rescue factor) receptor
  • MTRNR2L1 inhibits neuronal cell death and dysfunction by binding to a novel IL6-receptor-related receptor(s) on the cell surface involving CNTFR, IL27RA, and IL6ST
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS