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FLASH GENE

Symbol

IL23R

contributors: mct/npt - updated : 03-05-2018

HGNC name	interleukin 23 receptor
HGNC id	19100

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p31.3      Physical location : 67.632.168 - 67.725.648
Synonym symbol(s)	IL-23R, IBD17

DNA

TYPE	functioning gene
SPECIAL FEATURE	head to head
STRUCTURE	93.49 kb     11 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

within 150kb of the IL12RB2 gene

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_144701 11 splicing 2826 NP_653302 - 629 - Zhang (2006) variant 2 - splicing 1618 Isoform 2 - 138 predominantly detected in certain human lung carcinomas, but not in their resected normal margin tissues Zhang (2006) variant 3 - splicing 1676 isoform 3 - 264 - Zhang (2006) variant 4 - splicing 1609 isoform 4 - 320 predominantly detected in certain human lung carcinomas, but not in their resected normal margin tissues Zhang (2006) variant 3 - splicing 1676 isoform 1 - 320 - Zhang (2006)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage
cell lines	Kit225 T-cell line, Th1, ThO and NK cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal sequence
	an N-terminal Ig-like domain
	two cytokine receptor domains
	seven potential N-glycosylation sites

conjugated

GlycoP

mono polymer

complex

HOMOLOGY

Homologene

FAMILY	type I cytokine receptor family
	type 2 subfamily

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

having receptor activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

subunit of the receptor for IL23A/IL23

INTERACTION

DNA

RNA

small molecule

protein	pairing with the receptor molecule IL12RB1
	associating constitutively with JAK2
	binding to transcription activator STAT3 in a ligand-depedent manner
	ATG5, a key regulatory protein
	MYD88-dependent IL23R expression contributes to IL17A production
	RBPJ binds and trans-activates the IL23R promoter and induces IL23R expression and represses anti-inflammatory IL10 production in Th17 cells

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to inflammatory bowel disease(Crohn disease) to psoriasis to ankylosing spondylitis (AS)

Variant & Polymorphism other	variant confering strong protection against Crohn's disease
	two IL23R missense SNPs are common psoriasis-associated haplotype
	polymorphisms have been shown to have a significant association with ankylosing spondylitis (AS) (Sung 2009)

Candidate gene
Marker
Therapy target	potential therapeutic target in inflammatory bowel disease

ANIMAL & CELL MODELS