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FLASH GENE
Symbol IL20RA contributors: mct - updated : 13-12-2012
HGNC name interleukin 20 receptor, alpha
HGNC id 6003
Location 6q23.3      Physical location : 137.321.108 - 137.366.298
Synonym name
  • class II cytokine receptor ZCYTOR7
  • cytokine receptor family 2 member 8
  • Synonym symbol(s) ZCYTOR7, IL-20R1, CRF2-8, FLJ40993
    DNA
    TYPE functioning gene
    STRUCTURE 45.19 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3682 62.3 553 - 2002 12351624
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Nervousbrain    
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    Skin/Tegumentskin    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye anterior segment, lens, retina, optic nerve
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , dimer
    HOMOLOGY
    intraspecies homolog to IL10RB
    Homologene
    FAMILY
  • type II cytokine receptor family
  • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • IL20RA and IL10RB chains participate in forming the IL26 receptor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein IL20RB
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    dramatically upregulated in psoriatic skin
    Susceptibility to psoriasis
    Variant & Polymorphism SNP
  • haplotype CCG (rs1184860, rs1167846, rs1167849) is significantly associated with psoriasis
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS