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FLASH GENE
Symbol IL1RAP contributors: mct - updated : 31-10-2012
HGNC name interleukin 1 receptor accessory protein
HGNC id 5995
Location 3q28      Physical location : 190.231.839 - 190.374.985
Synonym name
  • interleukin-1 receptor accessory protein beta
  • Synonym symbol(s) FLJ37788, IL-1RAcP, IL1R3
    DNA
    TYPE functioning gene
    STRUCTURE 137.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    RPL39L 3q27 ribosomal protein L39-like MGC35450 3q28 hypothetical protein MGC35450 MASP1 3q27-q28 mannan-binding lectin serine protease 1 (C4/C2 activating component of Ra-reactive factor) IFRG28 3q28 28kD interferon responsive protein SST 3q28 somatostatin LOC344892 3q28 similar to Protein MGC35450/QtsA-16602 BCL6 3q27 B-cell CLL/lymphoma 6 (zinc finger protein 51) LOC389185 3 LOC389185 LPP 3q27-q28 LIM domain containing preferred translocation partner in lipoma FLJ41238 3q28 FLJ41238 protein TP73L 3q28 tumor protein p73-like MLAT4 3q29 myxoid liposarcoma associated protein 4 LOC391603 3 similar to nicotinamide nucleotide adenylyltransferase 1; NMN adenylyltransferase; pyridine nucleotide adenylyltransferase 1 CLDN1 3q28-q29 claudin 1 CLDN16 3q28-q29 claudin 16 LOC131920 3q29 hypothetical gene LOC131920 IL1RAP 3q28 interleukin 1 receptor accessory protein LOC391604 3 similar to Probable ATP-dependent helicase DHX34 (DEAH-box protein 34) LOC344901 URP 3q29 urotensin II-related peptide C3orf6 3q29 chromosome 3 open reading frame 6 LOC152138 3q29 similar to PYRIN-containing APAF1-like protein 2 (NACHT-, LRR- and PYD-containing protein 2) (Nucleotide-binding site protein 1) LOC131086 3q29 similar to microtubule-associated protein 6 FGF12 3q29-qter fibroblast growth factor 12 LOC151963 3q29 similar to BcDNA:GH11415 gene product LOC285388 3q29 similar to vascular endothelial zinc finger 1 HRASLS 3q28-q29 HRAS-like suppressor DKFZp761I1011 3q29 hypothetical protein DKFZp761I1011 OPA1 3q28-q29 optic atrophy 1 (autosomal dominant)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4726 - 570 - Li
    - - 2063 - 356 - Li
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta  highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • an extracellular domain with three Ig-like motifs
  • a transmembrane segment
  • box 3 is critical for IL-1-dependent NF-kappaB activation and stabilization of IL2 mRNA via JNK, whereas AA 527-534 largely contribute to IL2 promoter activation
  • a cytoplasmic domain with the homology to the Toll receptor family
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • required for the recruitment of IRAK(1) to the interleukin 1 receptor complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MARCH8-mediated polyubiquitination and degradation of IL1RAP is an important mechanism for negative regulation of IL1B-induced signaling pathways
  • IL33 signals through its ligand-binding primary receptor IL1RL1 and IL1 receptor accessory protein (IL1RAP)
  • cell & other
    REGULATION
    induced by IL1A or IL1B
    Other polyubiquitination and degradation by MARCH8
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS