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FLASH GENE
Symbol IL1R2 contributors: mct/npt - updated : 29-05-2010
HGNC name interleukin 1 receptor, type II
HGNC id 5994
Location 2q11.2      Physical location : 102.608.305 - 102.644.880
Synonym name
  • CD121 antigen-like family member B
  • type II interleukin-1 receptor, beta
  • antigen CDw121b
  • CD121 antigen
    • Synonym symbol(s) IL1RB, CD121b, MGC47725, CDw121b, IL-1R-2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 36.58 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    text regulated by alternate splicing, and the major inhibitory function is attributed to the full-length IL1R2 (Vambutas 2009)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1484 - 398 - Symons (1995), Vambutas (2009)
    9 - 1436 - 398 - Symons (1995), Vambutas (2009)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a ligand binding domain
  • three Ig-like domain
  • a single transmembrane domain
  • a short cytoplasmic domain lacking the Drosophila Toll signal (see IL1R1)
    • isoforms Precursor with a transmembrane isoform and an alternatively spliced soluble form (secreted)
    HOMOLOGY
    Homologene
    FAMILY
  • interleukin-1 receptor family
    • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text transmembrane protein
    basic FUNCTION
  • molecular decoy that traps interleukin-1beta (IL1B) and does not initiate subsequent signaling events, thereby suppressing an inflammatory response (Vambutas 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by by dexamethasone (Vambutas 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    appears to be a protective mechanism in hearing homeostasis (Vambutas 2009)
    constitutional     --over  
    results in changes in cell morphology, actin rearrangement, and promoted cell migration, through activation of the pre-interleukin 1alpha pathway (Chang 2009)
    Susceptibility to ankylosing spondylitis
    Variant & Polymorphism
    Candidate gene may be a specific biomarker for Autoimmune Inner Ear Disease (AIED) (Vambutas 2009)
    Marker
    Therapy target can neutralize IL1 beta and counteract its effect on endometrial stromal cells, and may provide a new clinical strategy for the treatment of endometriosis (Hou 2008)
    ANIMAL & CELL MODELS