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FLASH GENE

Symbol

IL1F7

contributors: mct - updated : 15-02-2012

HGNC name	interleukin 1 family, member 7 (zeta)
HGNC id	15563

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2q13      Physical location : 113.670.547 - 113.676.456
Synonym name	L related protein 1, family of interleukin 1, zeta
	interleukin 1 homolog 4
	interleukin-1 superfamily z
	IL-1X protein
Synonym symbol(s)	IL1RP1, FIL1, FIL1Z, IL1H4, IL37, FIL1(ZETA), IL-1F7, IL-1X

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	5.91 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

text structure

four coding exons

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

iIL1 related genes on chromosome 2

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014439 5 - 787 NP_055254 - 218 - 2000 10860666 NM_173202 4 - 724 NP_775294 - 197 - 2000 10860666 NM_173203 3 - 604 NP_775295 - 157 - 2000 10860666 NM_173204 4 - 667 NP_775296 - 178 - 2000 10860666 NM_173205 4 - 667 NP_775297 - 192 - 2000 10860666

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis       Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Epithelial barrier/lining epidermis stratum granulosum   Epithelial barrier/lining       Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage	hematopoietic cell lines
cell lines
fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a prodomain (15 to 30 AA),cleaved by CASP1

isoforms

Precursor

HOMOLOGY

Homologene

FAMILY

interleukin 1 family

CATEGORY

signaling cytokine

SUBCELLULAR LOCALIZATION	extracellular
text	translocates to the nucleus after caspase-1 processing and may act as a transcriptional modulator reducing the production of LPS-stimulated proinflammatory cytokines

basic FUNCTION	emerges as a natural suppressor of innate inflammatory and immune responses
	may be an anti-inflammatory member of the IL1 family

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense , inflammation

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

DEFB103B up-regulated the mRNA and protein expression of IL1F7

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS