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FLASH GENE
Symbol IL1F7 contributors: mct - updated : 15-02-2012
HGNC name interleukin 1 family, member 7 (zeta)
HGNC id 15563
Location 2q13      Physical location : 113.670.547 - 113.676.456
Synonym name
  • L related protein 1, family of interleukin 1, zeta
  • interleukin 1 homolog 4
  • interleukin-1 superfamily z
  • IL-1X protein
  • Synonym symbol(s) IL1RP1, FIL1, FIL1Z, IL1H4, IL37, FIL1(ZETA), IL-1F7, IL-1X
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 5.91 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure four coding exons
    MAPPING cloned Y linked N status provisional
    Physical map
    ANAPC1 2q12.1 anaphase-promoting complex 1 (meiotic checkpoint regulator) MERTK 2q14.1 c-mer proto-oncogene tyrosine kinase FLJ14681 2q13 hypothetical protein FLJ14681 FLJ37440 2q13 hypothetical protein FLJ37440 LOC84524 2q13 zinc finger protein FLJ41410 2q13 FLJ41410 protein LOC389020 2 similar to RAN-binding protein 2-like 1 isoform 1; sperm membrane protein BS-63; RAN-binding protein 2-like 1 TTL 2q13 similar to RAN-binding protein 2-like 1 isoform 1; sperm membrane protein BS-63; RAN-binding protein 2-like 1 POLR1B 2q13 polymerase (RNA)1polypeptide B, 128kDa C2orf9 2q13 chromosome 2 open reading frame 9 SLC20A1 2q11-q14 solute carrier family 20 (phosphate transporter), member 1 FLJ40629 2q14.1 hypothetical protein FLJ40629 IL1A 2q13 interleukin 1, alpha IL1B 2q13 interleukin 1, beta IL1F7 2q12.1-q14.1 interleukin 1 family, member 7 (zeta) IL1F9 2q13 interleukin 1 family, member 9 IL1F6 2q12-q14.1 interleukin 1 family, member 6 (epsilon) IL1F8 2q12-q14.1 interleukin 1 family, member 8 (eta) IL1F5 2q12.1 interleukin 1 family, member 5 (delta) IL1F10 2q12 interleukin 1 family, member 10 (theta) IL1RN 2q13-q14.2 interleukin 1 receptor antagonist TIC 2q13 interleukin 1 receptor antagonist PAX8 2q12-q14 paired box gene 8 LOC391427 2 similar to Ig kappa chain precursor V region (orphon V108) - human  (fragment) CBWD2 2q13 COBW domain containing 2 FOXD4L1 2q13 COBW domain containing 2 LOC284964 2q14.1 similar to bA395L14.5 (novel phosphoglucomutase like protein) LOC389021 2 hypothetical gene supported by BC063555 MGC13005 2q14.1 hypothetical protein MGC13005 RPL23AP7 2q14 ribosomal protein L23a pseudogene 7 RABL2A 2q13 RAB, member of RAS oncogene family-like 2A bA395L14.12 2q14.1 u2 small nuclear ribonucleoprotein polypeptide A' pseudogene bA395L14.13 2q14.1 acrosin-like protease SLC35F5 2q14.1 solute carrier family 35, member F5 ACTR3 2q13 ARP3 actin-related protein 3 homolog (yeast) LOC284968 2q14.1 hypothetical LOC284968
    regionally located iIL1 related genes on chromosome 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 787 - 218 - 2000 10860666
    4 - 724 - 197 - 2000 10860666
    3 - 604 - 157 - 2000 10860666
    4 - 667 - 178 - 2000 10860666
    4 - 667 - 192 - 2000 10860666
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Epithelialbarrier/liningepidermisstratum granulosum 
    Epithelialbarrier/lining   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage hematopoietic cell lines
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a prodomain (15 to 30 AA),cleaved by CASP1
  • isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • interleukin 1 family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    text translocates to the nucleus after caspase-1 processing and may act as a transcriptional modulator reducing the production of LPS-stimulated proinflammatory cytokines
    basic FUNCTION
  • emerges as a natural suppressor of innate inflammatory and immune responses
  • may be an anti-inflammatory member of the IL1 family
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DEFB103B up-regulated the mRNA and protein expression of IL1F7
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS