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FLASH GENE
Symbol IL17RE contributors: mct/npt - updated : 10-04-2010
HGNC name interleukin 17 receptor E
HGNC id 18439
Location 3p25.3      Physical location : 9.944.295 - 9.958.082
Synonym name IL-17 receptor E
Synonym symbol(s) FLJ23658, IL-17RE, MGC71884
DNA
TYPE functioning gene
STRUCTURE 13.78 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 2717 74 667 - Clark et al (03)
  • variant 1
  • differs in the 5' UTR as compared to variant 5. Both variants 1 and 5 encode the longest isoform
  • 14 splicing 2581 - 551 - Clark et al (03)
  • variant 2
  • has a shorter N-terminus as compared to isoform 1
  • 17 splicing 2729 74 667 - Clark et al (03)
  • variant 5
  • differs in the 5'UTR as compared to variant 1
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • conserved IL17R region
  • a SEFIR domain, lacking certain elements found in prototypical TIR domains, potentially explaining why they do not engage TIR-containing adaptors (Gaffen 2009)
  • HOMOLOGY
    Homologene
    FAMILY
  • IL17 family
  • CATEGORY immunity/defense , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may have a receptor activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • its ligand is IL17C (Gaffen 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS