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FLASH GENE

Symbol

IL17RD

contributors: mct/npt - updated : 07-05-2008

HGNC name	interleukin 17 receptor D
HGNC id	17616

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3p14. 3      Physical location : 57.124.011 - 57.199.403
Synonym name	similar expression to fgf genes
	interleukin-17 receptor-like protein
	Sef homolog
Synonym symbol(s)	SEF, IL17RLM, FLJ35755, IL-17RD, DKFZp434N1928, IL17Rhom, MGC133309

DNA

TYPE	functioning gene
SPECIAL FEATURE	head to head
STRUCTURE	80.00 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed SEF Ia - splicing 4478 66.8 595 ubiquitous but not in thyroid Preger SEF I b - splicing 2364 - 707 restricted pattern of ewpressionin testis and thyroid Preger inhibiting FGF-induced cell proliferation and preventing the activation of mitogen-activated protein kinase variant 1 14 - 8736 - 739 - Ren (2008)         - 739 - Ren (2008)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly Endocrine thyroid       highly Nervous brain diencephalon epithalamus pineal gland highly Reproductive female system ovary     highly   female system breast     highly   male system prostate     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	conserved IL17R region, a SEFIR domain, lacking certain elements found in prototypical TIR domains, potentially explaining why they do not engage TIR-containing adaptors (Gaffen 2009)
	cytoplasmic tail required for its ability to inhibit signalling and associate with FGFR, but the extracellular domain is dispensable (Gaffen 2009)

mono polymer

homomer , complex

HOMOLOGY

Homologene

FAMILY

IL17 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
text	type 1 membrane protein

basic FUNCTION	acting as a modulator of FGF signaling as a result of specific inhibition of p42/p44 ERK
	playing a positive role in the EGFR-mediated MAPK signaling pathway
	having a tumor suppressor-like role, and loss of IL17RD expression is a common mechanism in epithelial neoplasia (Zisman-Rozen 2007)
	inhibitor of RTK signaling, in normal epithelial tissues and derived malignancies (Zisman-Rozen 2007)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts with FGFR1 and FGFR2
	interacts with FGF receptors (FGFRs) and inhibits FGF signaling, however, its role in regulating epidermal growth factor receptor (EGFR) signaling remains unclear
	can also interact with IL17RA (Gaffen 2009)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in advanced prostate cancer and might facilitate an enhanced tumorigenic response to FGFs

Susceptibility

to congenital Hypogonadotropic Hypogonadism

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS