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FLASH GENE
Symbol IL17RA contributors: npt/mct - updated : 13-09-2017
HGNC name interleukin 17 receptor A
HGNC id 5985
Corresponding disease
IMD51 Immunodeficiency 51
Location 22q11.1      Physical location : 17.565.848 - 17.591.387
Synonym name
  • interleukin 17 receptor
  • CD217 antigen
  • IL-17 receptor
  • Synonym symbol(s) hIL-17R, IL-17RA, CDw217, IL17R, MGC10262, CANDF5, CD217, IL17R, IMD51
    DNA
    TYPE functioning gene
    STRUCTURE 30.73 kb     13 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map see ATP6V1E
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3429 96 866 - 2013 24084331
    12 - 8506 - 832 - 2013 24084331
  • spliced out of exon 11 encoding the transmembrane region in a variety of human tissues
  • soluble IL17RA isoform sheding new light on the regulation of IL7RA mediated responses
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Endocrinepancreas    
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    Membrane    
    skeletonsynovium   
    cell lineage hematopoietic
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 293 AA extracellular domain
  • seven potential N-linked glycosylation sites
  • conserved IL17R region, a SEFIR domain, lacking certain elements found in prototypical TIR domains, potentially explaining why they do not engage TIR-containing adaptors (Gaffen 2009), and an extended SEFIR domain is required for IL17RA-mediated signal transduction
  • TILL domain seems to be unique to IL17RA, perhaps explaining why IL17RA functions as a common subunit shared by several receptors in the family (Gaffen 2009)
  • 525 AA cytoplasmic tail
  • conjugated GlycoP
    mono polymer trimer
    HOMOLOGY
    interspecies homolog to murine Il17r
    Homologene
    FAMILY
  • IL17 family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text type 1 membrane protein
    basic FUNCTION
  • involved in IL17-induced signaling
  • with IL17A, activates genes typical of innate immune cytokines, such as TNFalpha and IL-1beta, despite minimal sequence similarity in their respective receptors (Maitra 2007)
  • could be analogous to shared cytokine receptor subunits, such as IL6ST, which is a common signal transducer for molecules of the IL-6 family (Gaffen 2009)
  • functional roles for both IL17RB and IL17RA in mediating IL25-induced activities (Rickel 2008)
  • role of IL17RA-independent mechanisms in causing autoimmunity and its regulation by TGF-beta
  • exhibits signaling properties that are nonredundant with other IL17R family members
  • IL17A/IL17RA axis increases aortic arch inflammation during atherogenesis through the induction of aortic chemokines, and the acceleration of neutrophil and monocyte recruitment to this site
  • IL17RA signal seems to be protective against infection-induced periapical inflammation and bone destruction via suppression of neutrophil and mononuclear inflammation
  • IL17A signaling via IL17RA contributes to the inflammatory host response by inducing recruitment of innate immune cells, but also plays a role in homeostatic neutrophilic granulocyte regulation
  • IL17RA appears to be a novel modulator of monocyte phenotype and possible therapeutic target in renal fibrosis
  • TLR signaling can directly stimulate the expression of IL17RA, in neuroglial cells, which functionally respond to IL17A by secreting chemokines, accelerating CD4 cell migration, and contributing to the pathogenesis of encephalomyelitis
  • IL17RA signals directly within transformed colonic epithelial cells (enterocytes) to promote early tumor development
  • expression of IL17RA plays an important role in gastric cancer progression, migration and prognosis
  • protective role for IL17RA signaling in regulation of the skin barrier and maintenance of skin immune homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with IL25
  • can also interact with IL17RD (Gaffen 2009)
  • functional roles for both IL17RB and IL17RA in mediating IL25-induced activities
  • TRAF3 is a receptor proximal negative regulator of IL17 receptor (IL17RA) signaling
  • BCL11A is required for expression of I7 receptor (IL7RA) and FLT3 in early hematopoietic progenitor cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) IMD51
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer tissues compared with adjacent normal tissues
    tumoral     --over  
    in the invasive group of pituitary adenomas (pMID: 21279695)
    Susceptibility
  • to ankylosing spondylitis (AS), severe form
  • Variant & Polymorphism s4819554 minor allele G in the promoter of the IL17RA gene was associated with AS, severe form
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    IL17A and IL17RA are therapeutic targets in colorectal cancer
    ANIMAL & CELL MODELS
  • in the setting of influenza infection, IL17ra(-/-) mice showed significantly reduced levels of oxidized phospholipids, which have previously been shown to be an important mediator in several models of acute lung injury, including influenza infection