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FLASH GENE

Symbol

IL17F

contributors: mct/npt - updated : 28-06-2008

HGNC name	interleukin 17F
HGNC id	16404

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6p12.2      Physical location : 52.101.483 - 52.109.298
Synonym name	cytokine ML-1
Synonym symbol(s)	ML1, IL-17F, ML-1, IL24

DNA

TYPE	functioning gene
STRUCTURE	7.82 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_052872 3 - 808 NP_443104 - 163 - Seiderer (2008)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic monocyte

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

IL17F family

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	regulating cartilage matrix turnover, stimulating T cell proliferation and inhibiting angiogenesis
	potent inducer of CXCR3 in bronchial epithelial cells, having a regulatory role in airway inflammation
	inducing in a time-dependent fashion the expression of IL6 and IL8 in both primary bronchial epithelial cells (PBECs) and human umbilical vein endothelial cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

ligand if IL17RC

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in Crohn disease

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	IL17F-CXCR3 axis might be a novel and critical therapeutic target for airway inflammatory diseases

ANIMAL & CELL MODELS