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FLASH GENE
Symbol IL15RA contributors: mct - updated : 09-04-2013
HGNC name interleukin 15 receptor, alpha
HGNC id 5978
Location 10p15-p14      Physical location : 5.994.334 - 6.020.142
DNA
TYPE functioning gene
STRUCTURE 25.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
regionally located tightly linked to IL2RA
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1843 - 231 - Mortier
- - 1610 - 267 - Mortier
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 intestinesmall intestine  highly
Endocrineneuroendocrinepituitary  highly
Nervousbrain   highly Homo sapiensAdult
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral    Homo sapiensAdult
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one short consensus repeat
  • sushi structure (see F13B, SRCP1)
  • HOMOLOGY
    Homologene
    FAMILY interleukin family
    CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • cytokine receptor that specifically binds IL15 with high affinity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • IL15 is produced potentially and secreted only as a heterodimer with IL15RA(
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IL15 may influence neural cell differentiation through a signal transduction pathway involving IL15RA and STAT3
  • IL15 can signal via IL15RA, JNK, and NFKB1 to drive CCL5 production by myeloid cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS