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FLASH GENE
Symbol IL13RA2 contributors: mct - updated : 25-08-2007
HGNC name interleukin 13 receptor, alpha 2
HGNC id 5975
Location Xq13.1-q28      Physical location : 114.238.538 - 114.252.207
Synonym name
  • interleukin 13 binding protein
  • Synonym symbol(s) IL13R, ILI3BP, CD213A2
    DNA
    TYPE like-sequence
    STRUCTURE 13.00 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (CAAT box)
    Binding site   transcription factor
    text structure
  • three TATA boxes and one CCAAT site
  • several putative transcriptional factor binding sites for nuclear factor of activated T cells 1, AP1 (c-JUN and c-FOS), AP2, GABP, OCT1, GATA3, PRE, and C-ETS1 were predicted in the promoter region
  • a 64 base pair (bp) region t is necessary for IL-13Ra2 promoter activity
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
    Reproductivefemale systemuterus   
     male systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text only in placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal FBN- type III like domain
  • a short C terminal intracellular tail
  • the WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor bindi
  • isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • may be involved in susceptibility to systemic sclerosis
  • play a role in the internalization of IL13
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component subuint of the interleukin 13 receptor complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to systemic sclerosis
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS