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FLASH GENE
Symbol IL13RA2 contributors: mct - updated : 25-08-2007
HGNC name interleukin 13 receptor, alpha 2
HGNC id 5975
Location Xq13.1-q28      Physical location : 114.238.538 - 114.252.207
Synonym name
  • interleukin 13 binding protein
  • Synonym symbol(s) IL13R, ILI3BP, CD213A2
    DNA
    TYPE like-sequence
    STRUCTURE 13.00 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (CAAT box)
    Binding site   transcription factor
    text structure
  • three TATA boxes and one CCAAT site
  • several putative transcriptional factor binding sites for nuclear factor of activated T cells 1, AP1 (c-JUN and c-FOS), AP2, GABP, OCT1, GATA3, PRE, and C-ETS1 were predicted in the promoter region
  • a 64 base pair (bp) region t is necessary for IL-13Ra2 promoter activity
  • MAPPING cloned Y linked N status confirmed
    Physical map
    DCX Xq22.3-q23 doublecortex; lissencephaly, X-linked (doublecortin) LOC392521 X similar to High mobility group protein 1-like 10 (HMG-1L10) LOC389880 X hypothetical gene supported by AB076839; NM_001417 LOC392522 X similar to 60S ribosomal protein L18a MDS031 Xq23 uncharacterized hematopoietic stem/progenitor cells protein MDS031 FLJ23018 Xq23 hypothetical protein FLJ23018 TRPC5 Xq23-q24 transient receptor potential cation channel, subfamily C, member 5 LOC389881 X similar to hypothetical protein FLJ13646 LOC340595 Xq23 similar to zinc finger, CCHC domain containing 5 LHFPL1 Xq23 lipoma HMGIC fusion partner-like 1 LOC203510 Xq23 similar to high mobility group protein homolog HMG4 AMOT Xq23 angiomotin LOC139466 Xq23 peptidyl prolyl isomerase H (cyclophilin H) pseudogene LOC286528 Xq24 similar to HSPC182 protein HTR2C Xq24 5-hydroxytryptamine (serotonin) receptor 2C IL13RA2 Xq24 interleukin 13 receptor, alpha 2 LOC392524 X similar to YAP1 protein KIAA1495 Xq24 KIAA1495 protein TMSL7 X thymosin-like 7 FLJ40249 Xq24 hypothetical protein FLJ40249 HOM-TES-85 Xq24 HOM-TES-85 tumor antigen PLS3 Xq24 plastin 3 (T isoform) ASSP5 Xq22-q26 argininosuccinate synthetase pseudogene 5 LOC136337 Xq24 similar to elongation factor 1 gamma LOC222019 Xq24 hypothetical gene supported by BC022340; L76416 LOC392525 X similar to Aldo-keto reductase family 1, member B1 LOC286533 Xq24 similar to apoptosis inhibitor 5; fibroblast growth factor 2-interacting factor 2; API5-like 1 AGTR2 Xq22-q23 angiotensin II receptor, type 2 SLC6A14 Xq23-q24 solute carrier family 6 (neurotransmitter transporter), member 14 LOC203413 Xq24 hypothetical LOC203413 LOC392526 X similar to Serine/threonine-protein kinase PRP4 homolog (PRP4 pre-mRNA processing factor 4 homolog) (Pre-mRNA protein kinase) LOC392527 X similar to protein phosphatase 2A inhibitor-2 I-2PP2A KIAA1309 Xq23-q24 KIAA1309 LOC392528 X similar to beta-tubulin 1 DKFZp686L20145 Xq24 similar to rab11-binding protein LOC389882 X LOC389882 DOCK11 Xq24 dedicator of cytokinesis 11 IL13RA1 Xq22-q26 interleukin 13 receptor, alpha 1
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
    Reproductivefemale systemuterus   
     male systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text only in placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal FBN- type III like domain
  • a short C terminal intracellular tail
  • the WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor bindi
  • isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • may be involved in susceptibility to systemic sclerosis
  • play a role in the internalization of IL13
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component subuint of the interleukin 13 receptor complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to systemic sclerosis
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS