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FLASH GENE
Symbol IL13RA1 contributors: mct - updated : 29-11-2014
HGNC name interleukin 13 receptor, alpha 1
HGNC id 5974
Location Xq24      Physical location : 117.861.558 - 117.928.495
Synonym name
  • IL13 receptor alpha-1 chain
  • CD213a1 antigen
  • cancer/testis antigen 19
  • Synonym symbol(s) IL13RA, NR4, CD213a1, IL13R, IL-13RA-, CT19, RP13-128O4.2
    DNA
    TYPE functioning gene
    STRUCTURE 66.94 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KIAA1309 Xq23-q24 KIAA1309 LOC392528 X similar to beta-tubulin 1 DKFZp686L20145 Xq24 similar to rab11-binding protein LOC389882 X LOC389882 DOCK11 Xq24 dedicator of cytokinesis 11 IL13RA1 Xq22-q26 interleukin 13 receptor, alpha 1 LOC170261 Xq24 hypothetical protein LOC170261 LOC159007 Xq24 similar to Aflatoxin B1 aldehyde reductase member 2 (AFB1-AR 1) (Aldoketoreductase 7) LOC392529 X hypothetical gene supported by NM_015198 RNF127 Xq24 ring finger protein 127 KIAA1210 Xq24 KIAA1210 protein LOC389883 X similar to Hnrpa1 protein PGRMC1 Xq22-q24 progesterone receptor membrane component 1 LOC139516 Xq24 similar to DNA segment on chromosome X and Y (unique) 155 expressed sequence; Pseudoautosomal gene XE7 (Y chromosome) MRPS17P9 Xq24 similar to DNA segment on chromosome X and Y (unique) 155 expressed sequence; Pseudoautosomal gene XE7 (Y chromosome) LOC203427 Xq24 similar to solute carrier family 25 , member 16 SLC25A5 Xq24-q26 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 FLJ22965 Xq23 hypothetical protein FLJ22965 UBE2A Xq24-q25 ubiquitin-conjugating enzyme E2A (RAD6 homolog) NRF Xq24-q25 ubiquitin-conjugating enzyme E2A (RAD6 homolog) SEPT6 Xq24 ubiquitin-conjugating enzyme E2A (RAD6 homolog) LOC347454 Xq25 similar to hypothetical protein A630014H24 RPL39 Xq22.1-q22.2 ribosomal protein L39 LOC158796 Xq25 similar to UPF3 regulator of nonsense transcripts homolog B isoform 2 UPF3B Xq25-q26 UPF3 regulator of nonsense transcripts homolog B (yeast) ZNF183 Xq24-q25 zinc finger protein 183 (RING finger, C3HC4 type) NDUFA1 Xq24 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa AKAP28 Xq25 A-kinase anchor protein 28 NKAP Xq25 NF-kappaB activating protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 4006 47 427 - 1999 10409622
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage Homo sapiens
    Lymphoid/ImmuneT cell Homo sapiens
    Respiratoryalveoli
    cell lineage
    cell lines glioma cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • putative signal sequence
  • transmembrane domain
  • a N terminal FBN-type III like domain
  • two typical cytokine receptor like modules with the consensus WSEWS motif
  • a short cytoplasmic tail
  • HOMOLOGY
    interspecies homolog to murine Il13ra
    Homologene
    FAMILY
  • type I cytokine receptor family
  • type 5 subfamily
  • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • might be involved in the control of immunoglobulin E production
  • essential for allergen-induced airway hyperreactivity and mucus hypersecretion but not for fibroblast or alternative macrophage activation
  • can potentially regulates IL4-induced responses in the lung
  • essential for baseline IgE production, but Th2 and IgE responses to T cell-dependent antigens are IL13RA1-independent
  • central role for the IL13/IL13RA1 pathway in the regulation of intestinal epithelial cell Cl(-) secretion via up-regulation of CFTR, suggesting an important role for this pathway in secretory diarrhea
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activating STAT6, jointly with IL4
  • ITGAM regulates IL13 activity in macrophages by directly interacting with IL13RA1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    at the transcriptional level in cisplastin-resistant cells
    constitutional     --over  
    on the suprabasal keratinocytes in the skin of atopic dermatitis and striking increase of staining was observed on all layers of keratinocyte in the skin of psoriasis
    Susceptibility
    Variant & Polymorphism SNP including a variant associated primarily with high IgE level
    Candidate gene
    Marker
  • loss of IL13RA1 on islet-reactive T cells may be a biomarker for fading regional immune regulation and progression to overt diabetes
  • Therapy target
    ANIMAL & CELL MODELS