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FLASH GENE
Symbol IL12B contributors: mct - updated : 20-09-2014
HGNC name interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
HGNC id 5970
Corresponding disease
IMD29 Immunodeficiency-29
Location 5q33.3      Physical location : 158.741.790 - 158.757.481
Synonym name
  • natural killer cell stimulatory factor, 40kDa subunit
  • natural killer cell stimulatory factor-2
  • cytotoxic lymphocyte maturation factor 2
  • IL12, subunit p40
  • interleukin-12 beta chain
  • CLMF p40
  • Synonym symbol(s) CLMF2, CLMF, NKSF, NKSF2, IL23, IL-12B, IMD28, IMD29, p40
    DNA
    TYPE functioning gene
    STRUCTURE 15.70 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure
  • promoter has a putative DNA-binding element for NFIL3
  • MAPPING cloned Y linked N status confirmed
    Map cen - D5S487 - D5S379 - D5S2912 - D5S2913 - D5S378 - ITK - IL12B - D5S2914 - D5S2915 - D5S412 - D5S2916 - qter
    Physical map
    LOC153743 5q33.3 similar to protein phosphatase 1, regulatory (inhibitor) subunit 2 LOC91937 5q33.3 hypothetical protein BC008988 HAVCR1 5q33.2 hepatitis A virus cellular receptor 1 HAVCR2 5q34 hepatitis A virus cellular receptor 2 CRSP9 5q33.2 cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa MGC26988 5q33.3 hypothetical protein MGC26988 ITK 5q33.1 IL2-inducible T-cell kinase CYFIP2 5q34 cytoplasmic FMR1 interacting protein 2 LOC348938 5q33.3 hypothetical protein LOC348938 ADAM19 5q32-q33 a disintegrin and metalloproteinase domain 19 (meltrin beta) SOX30 5q33 a disintegrin and metalloproteinase domain 19 (meltrin beta) LOC389341 5 similar to RIKEN cDNA 4921536K21 FLJ20546 5q33.3 hypothetical protein FLJ20546 LSM11 5q33.3 U7 snRNA-associated Sm-like protein ENTH 5q23.1-q33.3 U7 snRNA-associated Sm-like protein LOC391843 5 similar to 60S acidic ribosomal protein P2 LOC345471 5q33.3 similar to Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) LOC285721 5q33.3 hypothetical LOC285721 EBF 5q34 early B-cell factor FLJ31951 5q33.3 hypothetical protein FLJ31951 MGC10067 5q33.3 hypothetical protein MGC10067 IL12B 5q31.1-q33.1 interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) ADRA1B 5q33.1 adrenergic, alpha-1B-, receptor TTC1 5q32-q33.2 tetratricopeptide repeat domain 1 KIAA1935 5q34 KIAA1935 protein FABP6 5q23-q35 fatty acid binding protein 6, ileal (gastrotropin) FLJ14166 5q34 hypothetical protein FLJ14166 C1QTNF2 5q33.3 C1q and tumor necrosis factor related protein 2 LOC63920 5q34 transposon-derived Buster3 transposase-like SLU7 5q34 step II splicing factor SLU7 PTTG1 5q35.1 pituitary tumor-transforming 1 FLJ21477 5q34 hypothetical protein FLJ21477 GABRB2 5q33.1-q34 gamma-aminobutyric acid (GABA) A receptor, beta 2 GABRA6 5q33.1-q33.2 gamma-aminobutyric acid (GABA) A receptor, alpha 6 GABRA1 5q33.2 gamma-aminobutyric acid (GABA) A receptor, alpha 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2347 - 328 - 1991 1673147
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines PDBu-activated EBV-B cell lines secrete IL12A and IL12B
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one immunoglobulin-like C2 type domain
  • one fibronectin type III-like domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Il12b
    homolog to rattus Il12b
    Homologene
    FAMILY
  • cytokine receptor family
  • type 3 subfamily
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • chemotactic molecule for macrophages
  • can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine- activated killer cells, and stimulate the production of IFN-gamma
  • regulation of the Il12B gene, encoding the shared p40 subcomponent for IL12 and IL23, is critical for innate immune responses and subsequent T cell polarization
  • plays a critical role in enhancing the stability, intracellular trafficking, and export of the p35 subunit
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS immunity/defense
    text
  • IL12 is a signal of the innate immune system
  • growth factor for activated T and NK cells
  • PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with IL12A
  • heterodimeric cytokine composed of p40 and p35 subunits to yield IL-12p70
  • binary complex of a four-helix bundle cytokine (p19) and a soluble class I cytokine receptor p40
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • potent inducer of IFN gamma production
  • interacting with NFKBIZ (NFKBIZ is critical for activation of NK cells in response to IL12B and IL18)
  • NFIL3 is an IL12B transcriptional inhibitor
  • is negatively regulated at the transcriptional level by the STAT3 (signal transducer and activator of transcription 3)-activating anti-inflammatory cytokine IL10
  • HDAC3 is involved in histone deacetylation of the IL12B promoter by IL10
  • KLF10 is a transcription factor that regulates the expression of IL12B in bone marrow-derived macrophages (M-BMMs)
  • cell & other
  • driving development of Th1 cells
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) IMD29
    Susceptibility
  • to asthma
  • late onset of type 1 diabetes
  • to psoriasis
  • to cerebral malaria (CM)
  • to cervical cancer
  • to Takayasu arteritis
  • to inflammatory bowel disease (IBD)
  • to Tuberculosis
  • Variant & Polymorphism other
  • polymorphism in the promoter associated with severity of atopic asthma and non atopic in children
  • allele C of the 3'UTR associate with late onset of type 1 diabetes
  • highly significant association with an IL12B 3-untranslated-region SNP in psoriasis
  • heterozygous genotype corresponding to reduced IL-12p40 transcription and IL-12p70 production associated to cerebral malaria (low levels of IL12 production are associated with an increased risk of CM)
  • association of IL-12beta (1188A/C) gene polymorphism with the risk of cervical cancer
  • IL12B SNP rs6887695 modulates the susceptibility and the phenotype of IBD
  • genetic association between IL12B and Takayasu arteritis (rs56167332)
  • locus conferring strong resistance to Tuberculosis
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmune 
    antibodies specific as therapeutic targets in rheumatoid arthritis
    immunologyautoimmune 
    attractive targets for therapy of autoimmune diseases
    ANIMAL & CELL MODELS
    Il12b knock-out mice