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FLASH GENE
Symbol IL12A contributors: mct - updated : 14-04-2017
HGNC name interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
HGNC id 5969
Location 3q25.33      Physical location : 159.706.628 - 159.713.805
Synonym name
  • IL-12, subunit p35
  • NF cell stimulatory factor chain 1
  • cytotoxic lymphocyte maturation factor 1, p35
  • interleukin-12 alpha chain
    • Synonym symbol(s) CLMF1, NKSF1, IL-12A, NFSK, P35
    DNA
    TYPE functioning gene
    STRUCTURE 7.18 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1444 - 253 - 2007 17461482
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
    Lymphoid/Immunespleen    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine IL12A
    Homologene
    FAMILY
  • interleukin family
    • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • natural killer cell stimulatory factor 1
  • cytotoxic lymphocyte maturation factor 1
  • stimulating IFNG production
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS immunity/defense
    text growth factor for activated T and NK cells; IL12 is a signal of the innate immune system
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with IL12B
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • enhancement of SIRT1 activity in response to phagocytic stimuli may reduce the accessibility of REL to the IL12A promoter and its transcriptional activation, thus regulating the IL12 p70/IL12B balance and modulating the ongoing immune response
  • DDR2 is involved in the collagen I-induced IL12A production via NFKB1 and JNK pathway
  • MAP2K1 is required for TLR4 mediated ERK activation and in turn regulates the production of IL10 and IL12A
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric carcinoma with poor prognosis
    Susceptibility
  • to systemic lupus erythematosus patients (SLE)
  • to primary biliary cirrhosis (PBC)
    • Variant & Polymorphism SNP SNPs within SCHIP1 (located ~100 kb proximal to IL12A) showed suggestive association with PBC
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmuneLupus
    may be therapeutic targets in SLE
    ANIMAL & CELL MODELS