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FLASH GENE
Symbol IKZF5 contributors: - updated : 12-04-2007
HGNC name IKAROS family zinc finger 5 (Pegasus)
HGNC id 14283
Location 10q26      Physical location : 124.753.196 - 124.768.311
Synonym name
  • zinc finger transcription factor Pegasus
  • zinc finger protein, subfamily 1A, 5 (Pegasus)
  • Synonym symbol(s) PEGASUS, ZNFN1A5
    DNA
    TYPE functioning gene
    STRUCTURE 16.00 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text three Pegasus transcripts in hemopoietic cell lines and in tissues (OMIM)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
     vessel   highly
    Digestiveesophagus   moderately
     liver    
    Lymphoid/Immunelymph node   moderately
     spleen   moderately
     thymus   moderately
    Nervousbrain    
     nerve   predominantly
    Reproductivemale systemprostate   
    Respiratoryrespiratory tracttrachea  moderately
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Lymphoid    
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal clusters of zinc fingers domain important for DNA binding
  • a C-terminal clusters of zinc fingers domain that mediates homo- and heterotypic associations between family members
  • conjugated MetalloP
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Zfpn1a5 (98.3 pc)
    homolog to murine Zfpn1a5 (96.6 pc)
    homolog to chicken ZNFN1A5 (89.5 pc)
    Homologene
    FAMILY Ikaros family of transcription factors
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • implicated in the control of lymphoid development
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text
  • lymphoid development
  • transcriptional repressor
  • PATHWAY
    metabolism
    signaling
    a component
  • integral component of chromatin-remodeling complexes
  • homo or heterodimerizing with either other member of the family
  • INTERACTION
    DNA binding to GnnTGTnG
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS