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FLASH GENE
Symbol IKZF4 contributors: SGE - updated : 12-04-2007
HGNC name IKAROS family zinc finger 4 (Eos)
HGNC id 13179
Location 12q13.2      Physical location : 56.414.688 - 56.432.219
Synonym name
  • zinc finger protein, subfamily 1A, 4 (Eos)
  • Synonym symbol(s) EOS, KIAA1782, ZNFN1A4
    DNA
    TYPE functioning gene
    STRUCTURE 17.53 kb     8 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 5506 - 585 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveliver   lowly
    Hearing/Equilibriumearinnercochlea predominantly
    Lymphoid/Immunelymph node   moderately
     spleen   lowly
     thymus   lowly
    Urinarykidney   moderately
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines hematopoietic cell lines MOLT-4, NALM-6, K562, THP-1, Mo7e-IL3
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six C2H2 type zinc fingers
  • conjugated MetalloP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to chimpanzee ZNFN1A4 (100 pc)
    homolog to murine Zfpn1a4 (95.3 pc)
    Homologene
    FAMILY
  • IKAROS family of transcription factors
  • zinc finger subfamily 1A
  • S1 trypsin-like serine-protease family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • implicated in the control of lymphoid development
  • acting as a transcriptional repressor
  • critical mediator of FOXP3-dependent gene silencing in CD4+ regulatory T cells, via its interaction with FOXP3 and induction of chromatin modifications that result in gene silencing (Pan 2009)
  • may be involved in the development of central and preipheral nervous systems
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • integral component of chromatin-remodeling complexes
  • homo or heterodimerizing with either other member of the family IKZF1, IKZF2, IKZF3 and IKZF5
  • INTERACTION
    DNA binding to typical 5'-GGGAATRCC-3' Ikaros-binding sequences
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with SPI1; MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2
  • interacting with CTBP2
  • interacting with FOXP3 (Pan 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS