Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | IKZF3 | contributors: mct - updated : 19-11-2015 |
HGNC name | IKAROS family zinc finger 3 (Aiolos) |
HGNC id | 13178 |
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Location | 17q12 Physical location : 37.921.200 - 38.020.441 |
Synonym name | |
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Synonym symbol(s) | AIOLOS, ZNF1A3, EVI112, ZNFN1A3, AIO |
DNA |
TYPE | functioning gene |
STRUCTURE | 106.47 kb 8 Exon(s) |
regulatory sequence | Promoter |
Binding site transcription factor | |
text structure | |
|
MAPPING | cloned | Y | linked | N | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cells |
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cell lineage
cell lines
| fluid/secretion
| highly in lymph, moderately in blood | |
at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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conjugated | PhosphoP , MetalloP |
HOMOLOGY |
interspecies | homolog to murine Zfpn1a3 (87 pc) |
homolog to rattus Zfpn1a3 (87.9 pc) |
intraspecies | homolog to Ikaros,Aiolos |
Homologene |
FAMILY | |
|
CATEGORY | transcription factor |
SUBCELLULAR LOCALIZATION | plasma membrane |
intracellular | |
intracellular,cytoplasm | |
intracellular,nucleus,chromatin/chromosome |
basic FUNCTION | |
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CELLULAR PROCESS | cell life, differentiation |
nucleotide, chromatin organization, remodeling | |
nucleotide, transcription, regulation |
PHYSIOLOGICAL PROCESS | development |
text | mesoderm development |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA | binding |
RNA |
small molecule | metal binding, |
protein | |
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cell & other |
REGULATION |
Other | transcription factors Ikaros and NFKB involved in the control of Aiolos expression |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Other morbid association(s) |
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Susceptibility | to systemic lupus erythematosus |
Variant & Polymorphism SNP | |
Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |