basic FUNCTION
| differentiation of lymphocytes |
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involved in regulation of transcription, DNA-dependent |
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central role in T cell development and homeostasis, but it is not essential for T cells, and its function can be compensated for by other members of the Ikaros family |
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Ikaros family members are critical for a functional immune system that confers protection against invading pathogens, while minimising the risk of leukaemic transformation, immune pathology, and autoimmunity |
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IKZF2 expression is associated with T cell activation and cellular division |
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key regulator of IL2 expression in Tregs, contributing to the maintenance of the anergic phenotype |
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is the first marker known to diverge during positive and negative selection of thymocytes |
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IKZF2 and SATB1, are considered to be important in proper Treg development |