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FLASH GENE
Symbol IK contributors: mct - updated : 25-01-2014
HGNC name IK cytokine, down-regulator of HLA II
HGNC id 5958
Location 5q31.3      Physical location : 140.027.383 - 140.042.064
Synonym name
  • IK factor
  • RD element
  • RED protein
  • chondrosarcoma-associated protein 2
  • Synonym symbol(s) CSA2, MGC59741, RED
    DNA
    TYPE functioning gene
    STRUCTURE 14.68 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    FLJ20288 SLC35A4 5q31.3 solute carrier family 35, member A4 EIF4EBP3 5q31.3 eukaryotic translation initiation factor 4E binding protein 3 SRA1 5q31.3 steroid receptor RNA activator 1 APBB3 5q31 amyloid beta (A4) precursor protein-binding, family B, member 3 CD14 5q31.1 CD14 antigen PRO1580 5q31.3 hypothetical protein PRO1580 NDUFA2 5q31.2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa IK 2p15-p14 IK cytokine, down-regulator of HLA II FLJ20195 5q31.3 hypothetical protein FLJ20195 DND1 5q31.3 dead end homolog 1 (zebrafish) HARS 5q31.1 histidyl-tRNA synthetase HARSL 5q31.1-q33.2 histidyl-tRNA synthetase-like FLJ31121 5q31.3 hypothetical protein FLJ31121 PCDHA1 5q31.3 protocadherin alpha 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 1955 - 557 - 1999 10216252
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Lymphoid/Immunespleen   highly
     tonsils   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text
  • localizes to the spindle poles (PMI: 22351768)
  • is a spindle pole-associated protein but not a kinetochore-associated protein (PMI: 22351768)
  • basic FUNCTION
  • downregulating HLA class II expression on the cell surface
  • may participate in providing a microenvironment at the tumor site insensitive to interferon-gamma stimulation and thus prevents an efficient local immune response
  • acting as as a regulatory protein, possibly involved in transcription
  • down-regulator of human leukocyte antigen (HLA) II
  • is a spindle pole-associated protein that colocalizes with MAD1L1 at the spindle poles in metaphase and anaphase
  • is required for kinetochore localization of MAD1L1, mitotic progression, and activation of the spindle assembly checkpoint (SAC)
  • has a role in the activation of the SAC and in mitosis progression
  • may play a crucial role in implantation, during pregnancy
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IK interacts with the human SAC protein MAD1L1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cutaneous T cell lymphoma derived tumor cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS