Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol IGSF6 contributors: - updated : 09-01-2006
HGNC name immunoglobulin superfamily, member 6
HGNC id 5953
Location 16p13-p12      Physical location : 21.652.605 - 21.663.972
Synonym name down-regulated by activation (immunoglobulin superfamily)
Synonym symbol(s) DORA
DNA
TYPE functioning gene
SPECIAL FEATURE gene in gene
text embedded in an intron of a gene of unknown function
STRUCTURE 11.00 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - - 1000 25 241 - Bates
- - splicing 2500 - - immune system Bates
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
 thymus   lowly
Digestiveintestine   lowly
Lymphoid/Immunelymph node    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • single extracellular immunoglobulin like domain with potential N glycosylation site in the Ig loop Tyr residue in the transmembrane region
  • highly basic cytoplasmic region
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Igsf6
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CD8 family of receptors
  • CATEGORY immunity/defense , signaling , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • antigen uptake
  • homing of dendritic cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text antipathogen response
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other downregulated by CD40L (TNFSF5) activation of dendritic cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    localized to a locus involved in inflammatory bowel disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS