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FLASH GENE
Symbol IGSF3 contributors: mct - updated : 26-02-2015
HGNC name immunoglobulin superfamily, member 3
HGNC id 5950
Corresponding disease
LCDD lacrimal duct defect
Location 1p13.1      Physical location : 117.117.030 - 117.210.314
Synonym symbol(s) EWI-3, LCDD, V8
DNA
TYPE functioning gene
STRUCTURE 93.36 kb     11 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
AMPD1 1p13 adenosine monophosphate deaminase 1 (isoform M) NRAS 1p13.2 neuroblastoma RAS viral (v-ras) oncogene homolog D1S155E 1p22 NRAS-related gene FLJ21168 1p13.1 hypothetical protein FLJ21168 SYCP1 1p13 synaptonemal complex protein 1 TSHB 1p13 thyroid stimulating hormone, beta TSPAN-2 1p13.1 tetraspan 2 NGFB 1p13.1 nerve growth factor, beta polypeptide LOC391068 1 similar to mCAF1 protein VANGL1 1p11-p13.1 vang-like 1 (van gogh, Drosophila) LOC387624 1 hypothetical gene supported by NM_024062 CASQ2 1p13.3-p11 calsequestrin 2 (cardiac muscle) NHLH2 1p12-p11 nescient helix loop helix 2 LOC343019 1p12 similar to Hnrpa1 protein SLC22A15 1p12 solute carrier family 22 (organic cation transporter), member 15 FLJ38716 1p12 hypothetical protein FLJ38716 ATP1A1 1p13 ATPase, Na+/K+ transporting, alpha 1 polypeptide MGC16179 1p12 hypothetical protein MGC16179 LOC148766 1p12 hypothetical LOC148766 CD58 1p13 CD58 antigen, (lymphocyte function-associated antigen 3) IGSF3 1p13 immunoglobulin superfamily, member 3 LOC388667 1 LOC388667 LOC391069 1 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) LOC339396 1p12 similar to neurofilament, heavy polypeptide 200kDa; Neurofilament, heavy polypeptide; neurofilament, heavy polypeptide (200kD) CD2 1p13.1 CD2 antigen (p50), sheep red blood cell receptor PTGFRN 1p13.1-q21.3 prostaglandin F2 receptor negative regulator IGSF2 1p13 immunoglobulin superfamily, member 2 TTF2 1p13.1 transcription termination factor, RNA polymerase II TRIM45 1q12-21 tripartite motif-containing 45 LOC391070 1 similar to 40S ribosomal protein S15a B7-H4 1p12 immune costimulatory protein B7-H4 MAN1A2 1p13.1 mannosidase, alpha, class 1A, member 2 FLJ20202 1p12 FLJ20202 protein LOC391071 1 similar to voltage-dependent anion channel 2 GDAP2 1q21.1 ganglioside induced differentiation associated protein 2 WDR3 1p13-p12 WD repeat domain 3
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 7284 - 1194 - 1998 9790749
11 - 7205 - 1214 widely 1998 9790749
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemplacenta  highly Homo sapiensmRNA
Respiratorylung   highly Homo sapiensmRNA
Urinarykidney   highly Homo sapiensmRNA
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • immunoglobulin-like membrane protein with eight Ig domains,a EWI (Glu-Irp-Ile domain) and an intercysteine loop
  • a potential transmembrane segment and a charged cytoplasmic tail
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY immunoglobulin superfamily
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • immunoglobulin-like membrane protein
  • basic FUNCTION potentially involved in cell-surface recognition
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • SIN3A complex acts as a context-dependent ISGF3/STAT3 transcriptional switch
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LCDD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS