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FLASH GENE

Symbol

IGSF3

contributors: mct - updated : 26-02-2015

HGNC name	immunoglobulin superfamily, member 3
HGNC id	5950

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	LCDD lacrimal duct defect
Location	1p13.1      Physical location : 117.117.030 - 117.210.314
Synonym symbol(s)	EWI-3, LCDD, V8

DNA

TYPE	functioning gene
STRUCTURE	93.36 kb     11 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001007237 11 - 7284 NP_001007238 - 1194 - 1998 9790749 NM_001542 11 - 7205 NP_001533 - 1214 widely 1998 9790749

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system placenta     highly Homo sapiens mRNA Respiratory lung       highly Homo sapiens mRNA Urinary kidney       highly Homo sapiens mRNA

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	immunoglobulin-like membrane protein with eight Ig domains,a EWI (Glu-Irp-Ile domain) and an intercysteine loop
	a potential transmembrane segment and a charged cytoplasmic tail

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

immunoglobulin superfamily

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	plasma membrane
text	immunoglobulin-like membrane protein

basic FUNCTION

potentially involved in cell-surface recognition

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

SIN3A complex acts as a context-dependent ISGF3/STAT3 transcriptional switch

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

LCDD

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS