Selected-GenAtlas references SOURCE GeneCards NCBI Gene Ensembl IMGT
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol IGLV9-49 contributors: - updated : 24-11-2005
HGNC name immunoglobulin lambda variable 9-49
HGNC id 5933
Location 22q11.2      Physical location : -
Synonym symbol(s) HGNC5933, IGLV949, V5-2
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text member of one of the clusters of IGLV genes which is located at the proximal end of IGL@ (see symbol IGL@)
MAPPING cloned Y linked N status provisional
Physical map
TOP3B2 22q11.22 topoisomerase (DNA) III beta, 2 VPREB1 22q11.22 pre-B lymphocyte gene 1 LOC96610 22q11.22 hypothetical protein similar to KIAA0187 gene product IGLV5-52 22q11.2 immunoglobulin lambda variable 5-52 IGLV1-51 22q11.2 immunoglobulin lambda variable 1-51 IGLV1-50 22q11.2 immunoglobulin lambda variable 1-50 IGLV9-49 22q11.2 immunoglobulin lambda variable 9-49 IGLV5-48 22q11.2 immunoglobulin lambda variable 5-48 IGLV1-47 22q11.2 immunoglobulin lambda variable 1-47 IGLV7-46 22q11.2 immunoglobulin lambda variable 7-46 IGLV5-45 22q11.2 immunoglobulin lambda variable 5-45 IGLV1-44 22q11.2 immunoglobulin lambda variable 1-44 IGLV7-43 22q11.2 immunoglobulin lambda variable 7-43 IGLVI-42 22q11.2 immunoglobulin lambda variable (I)-42 IGLVVII-41-1 22q11.2 immunoglobulin lambda variable (VII)-41-1 IGLV1-41 22q11.2 immunoglobulin lambda variable 1-41 IGLV1-40 22q11.2 immunoglobulin lambda variable 1-40 ASH2LP1 22q11.22 ash2 (absent, small, or homeotic)-like (Drosophila) pseudogene 1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
 spleen    
 thymus    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood/Hematopoieticbone marrow   
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a sequence of some 110 aminoacids folded to form a compact immunoglobulin domain with both ends joined together by a disulfide bond
  • made of three hypervariable regions (complementary-determining regions) located on the N terminal part of the sequence
  • the remaining part being relatively constant and forming the framework
  • HOMOLOGY
    Homologene
    FAMILY Immunoglobulin superfamily
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • forming the antigen binding site together with the cognate region of the light chain
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text humoral immunity, antibody synthesis
    PATHWAY
    metabolism
    signaling
    a component
  • component of the immunoglobulin molecules which are tetramers of two identical heavy chains and two identicallight chains, either kappa or lambda, bound by disulfide bonds
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C-terminal end covalently bound to the DJ segment by the V(D)J recombination system (see RAG1, RAG2)
  • during the process, a random loss or gain of nucleotides occurs (junctional diversification)
  • bound by a disulfide bond to a variable light chain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS