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FLASH GENE
Symbol IGLV4-3 contributors: - updated : 24-11-2005
HGNC name immunoglobulin lambda variable 4-3
HGNC id 5919
Location 22q11.2      Physical location : -
Synonym symbol(s) HGNC5919, IGLV43, V5-1
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text member of one of the clusters of IGLV genes which is located at the proximal end of IGL@ (see symbol IGL@)
MAPPING cloned Y linked N status provisional
Physical map
IGLV2-11 22q11.2 immunoglobulin lambda variable 2-11 IGLV3-10 22q11.2 immunoglobulin lambda variable 3-10 IGLV3-9 22q11.2 immunoglobulin lambda variable 3-9 IGLV2-8 22q11.2 immunoglobulin lambda variable 2-8 IGLV3-7 22q11.2 immunoglobulin lambda variable 3-7 IGLV3-6 22q11.2 immunoglobulin lambda variable 3-6 IGLV2-5 22q11.2 immunoglobulin lambda variable 2-5 IGLV3-4 22q11.2 immunoglobulin lambda variable 3-4 IGLV4-3 22q11.2 immunoglobulin lambda variable 4-3 IGLV3-2 22q11.2 immunoglobulin lambda variable 3-2 IGLV3-1 22q11.2 immunoglobulin lambda variable 3-1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
 spleen    
 thymus    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood/Hematopoieticbone marrow   
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains a sequence of some 110 aminoacids folded to form a compact immunoglobulin domain with both ends joined together by a disulfide bond, made of three hypervariable regions (complementary-determining regions) located on the N terminal part of the sequence, the remaining part being relatively constant and forming the framework
HOMOLOGY
Homologene
FAMILY Immunoglobulin superfamily
CATEGORY immunity/defense
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
    intracellular
intracellular,cytoplasm
basic FUNCTION forming the antigen binding site together with the cognate region of the light chain
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS immunity/defense
text humoralimmunity, antibody synthesis
PATHWAY
metabolism
signaling
Component of the immunoglobulin molecules which are tetramers of two identical heavy chains and two identicallight chains, either kappa or lambda, bound by disulfide bonds
a component
INTERACTION
DNA
RNA
small molecule
protein
  • C-terminal end covalently bound to the DJ segment by the V(D)J recombination system (see RAG1, RAG2). During the process, a random loss or gain of nucleotides occurs (junctional diversification)
  • Bound by a disulfide bond to a variable light chain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS