Selected-GenAtlas references SOURCE GeneCards NCBI Gene Ensembl IMGT
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol IGLV3-19 contributors: - updated : 24-11-2005
HGNC name immunoglobulin lambda variable 3-19
HGNC id 5903
Location 22q11.2      Physical location : -
Synonym symbol(s) HGNC5903, IGLV319, V2-13, VL3L
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text member of one of the clusters of IGLV genes which is located at the proximal end of IGL@ (see symbol IGL@)
MAPPING cloned Y linked N status provisional
Physical map
IGLV2-33 22q11.2 immunoglobulin lambda variable 2-33 IGLV3-32 22q11.2 immunoglobulin lambda variable 3-32 IGLV3-31 22q11.2 immunoglobulin lambda variable 3-31 IGLV3-30 22q11.2 immunoglobulin lambda variable 3-30 BCRL4 22q11.22 breakpoint cluster region-like 4 LOC150236 22q11.22 similar to hypothetical protein DKFZp434K191 (H. sapiens) LOC157446 22q11.22 similar to rat nuclear pore membrane glycoprotein 121 kD POM121L1 22q11.1 POM121 membrane glycoprotein-like 1 (rat) GGTL4 22q11.21 gamma-glutamyltransferase-like 4 LOC157463 22q11.22 similar to gamma-glutamyltransferase-like activity 1 LOC129026 22q11.22 hypothetical gene similar to gamma-glutamyltransferase-like activity 1 IGLV3-29 22q11.2 immunoglobulin lambda variable 3-29 IGLV2-28 22q11.2 immunoglobulin lambda variable 2-28 IGLV3-27 22q11.2 immunoglobulin lambda variable 3-27 IGLV3-26 22q11.2 immunoglobulin lambda variable 3-26 IGLVVI-25-1 22q11.2 immunoglobulin lambda variable (VI)-25-1 IGLV3-25 22q11.2 immunoglobulin lambda variable 3-25 IGLV3-24 22q11.2 immunoglobulin lambda variable 3-24 IGLV2-23 22q11.2 immunoglobulin lambda variable 2-23 IGLVVI-22-1 22q11.2 immunoglobulin lambda variable (VI)-22-1 IGLV3-22 22q11.2 immunoglobulin lambda variable 3-22 IGLV3-21 22q11.2 immunoglobulin lambda variable 3-21 IGLVI-20 22q11.2 immunoglobulin lambda variable (I)-20
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
 spleen    
 thymus    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood/Hematopoieticbone marrow   
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a sequence of some 110 aminoacids folded to form a compact immunoglobulin domain with both ends joined together by a disulfide bond
  • made of three hypervariable regions (complementary-determining regions) located on the N terminal part of the sequence
  • the remaining part being relatively constant and forming the framework
  • HOMOLOGY
    Homologene
    FAMILY Immunoglobulin superfamily
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • forming the antigen binding site together with the cognate region of the light chain
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text humoral immunity, antibody synthesis
    PATHWAY
    metabolism
    signaling
    a component
  • component of the immunoglobulin molecules which are tetramers of two identical heavy chains and two identicallight chains, either kappa or lambda, bound by disulfide bonds
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C-terminal end covalently bound to the DJ segment by the V(D)J recombination system (see RAG1, RAG2)
  • during the process, a random loss or gain of nucleotides occurs (junctional diversification)
  • bound by a disulfide bond to a variable light chain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS