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FLASH GENE
Symbol IGLV3-10 contributors: - updated : 17-11-2005
HGNC name immunoglobulin lambda variable 3-10
HGNC id 5897
Location 22q11.2      Physical location : -
Synonym symbol(s) HGNC5897, IGLV310, V2-7
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text member of one of the clusters of IGLV genes which is located at the proximal end of IGL@ (see symbol IGL@)
MAPPING cloned Y linked N status provisional
Physical map
IGLV3-25 22q11.2 immunoglobulin lambda variable 3-25 IGLV3-24 22q11.2 immunoglobulin lambda variable 3-24 IGLV2-23 22q11.2 immunoglobulin lambda variable 2-23 IGLVVI-22-1 22q11.2 immunoglobulin lambda variable (VI)-22-1 IGLV3-22 22q11.2 immunoglobulin lambda variable 3-22 IGLV3-21 22q11.2 immunoglobulin lambda variable 3-21 IGLVI-20 22q11.2 immunoglobulin lambda variable (I)-20 IGLV3-19 22q11.2 immunoglobulin lambda variable 3-19 IGLV2-18 22q11.2 immunoglobulin lambda variable 2-18 IGLV3-17 22q11.2 immunoglobulin lambda variable 3-17 IGLV3-16 22q11.2 immunoglobulin lambda variable 3-16 IGLV3-15 22q11.2 immunoglobulin lambda variable 3-15 IGLV2-14 22q11.2 immunoglobulin lambda variable 2-14 IGLV3-13 22q11.2 immunoglobulin lambda variable 3-13 IGLV3-12 22q11.2 immunoglobulin lambda variable 3-12 IGLV2-11 22q11.2 immunoglobulin lambda variable 2-11
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
 spleen    
 thymus    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood/Hematopoieticbone marrow   
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a sequence of some 110 aminoacids folded to form a compact immunoglobulin domain with both ends joined together by a disulfide bond
  • made of three hypervariable regions (complementary-determining regions) located on the N terminal part of the sequence
  • the remaining part being relatively constant and forming the framework
  • HOMOLOGY
    Homologene
    FAMILY Immunoglobulin superfamily
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • forming the antigen binding site together with the cognate region of the light chain
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text humoral immunity, antibody synthesis
    PATHWAY
    metabolism
    signaling
    a component
  • component of the immunoglobulin molecules which are tetramers of two identical heavy chains and two identicallight chains, either kappa or lambda, bound by disulfide bonds
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C-terminal end covalently bound to the DJ segment by the V(D)J recombination system (see RAG1, RAG2)
  • during the process, a random loss or gain of nucleotides occurs (junctional diversification)
  • bound by a disulfide bond to a variable light chain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS