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FLASH GENE
Symbol IGKV3D-20 contributors: - updated : 17-11-2005
HGNC name immunoglobulin kappa variable 3D-20
HGNC id 5825
Location 2p11.2      Physical location : -
Synonym symbol(s) IGKV3D20, A11, A11a
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text member of the cluster of IGKV genes located at the proximal end of IGK@ (see symbol IGK@)
MAPPING cloned Y linked N status provisional
Physical map
IGKV2D-36 2p11.2 immunoglobulin kappa variable 2D-36 IGKV1D-35 2p11.2 immunoglobulin kappa variable 1D-35 IGKV3D-34 2p11.2 immunoglobulin kappa variable 1D-34 IGKV1D-33 2p11.2 immunoglobulin kappa variable 1D-33 IGKV1D-32 2p11.2 immunoglobulin kappa variable 1D-32 IGKV3D-31 2p11.2 immunoglobulin kappa variable 3D-31 IGKV2D-30 2p11.2 immunoglobulin kappa variable 2D-30 IGKV2D-29 2p11.2 immunoglobulin kappa variable 2D-29 IGKV2D-28 2p11.2 immunoglobulin kappa variable 2D-28 IGKV1D-27 2p11.2 immunoglobulin kappa variable 1D-27 IGKV2D-26 2p11.2 immunoglobulin kappa variable 2D-26 IGKV3D-25 2p11.2 immunoglobulin kappa variable 3D-25 IGKV2D-24 2p11.2 immunoglobulin kappa variable 2D-24 IGKV2D-23 2p11.2 immunoglobulin kappa variable 2D-23 IGKV1D-22 2p11.2 immunoglobulin kappa variable 1D-22 IGKV6D-21 2p11.2 immunoglobulin kappa variable 6D-21 IGKV3D-20 2p11.2 immunoglobulin kappa variable 3D-20 IGKV2D-19 2p11.2 immunoglobulin kappa variable 2D-19 IGKV2D-18 2p11.2 immunoglobulin kappa variable 2D-18 IGKV6D-41 2p11.2 immunoglobulin kappa variable 6D-41 IGKV1D-17 2p11.2 immunoglobulin kappa variable 1D-17 IGKV1D-16 2p11.2 immunoglobulin kappa variable 1D-16 IGKV3D-15 2p11.2 immunoglobulin kappa variable 3D-15 IGKV2D-14 2p11.2 immunoglobulin kappa variable 2D-14
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
 spleen    
 thymus    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood/Hematopoieticbone marrow   
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a sequence of some 110 aminoacids folded to form a compact immunoglobulin domain with both ends joined together by a disulfide bond
  • made of three hypervariable regions (complementary-determining regions) located on the N terminal part of the sequence
  • the remaining part being relatively constant and forming the framework
    • HOMOLOGY
    Homologene
    FAMILY Immunoglobulin superfamily
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • forming the antigen binding site together with the cognate region of the light chain
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text humoral immunity, antibody synthesis
    PATHWAY
    metabolism
    signaling
    a component
  • component of the immunoglobulin molecules which are tetramers of two identical heavy chains and two identicallight chains, either kappa or lambda, bound by disulfide bonds
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C-terminal end covalently bound to the DJ segment by the V(D)J recombination system (see RAG1, RAG2)
  • during the process, a random loss or gain of nucleotides occurs (junctional diversification)
  • bound by a disulfide bond to a variable light chain
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS