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FLASH GENE
Symbol IGKV2-24 contributors: - updated : 17-11-2005
HGNC name immunoglobulin kappa variable 2-24
HGNC id 5781
Location 2p11.2      Physical location : -
Synonym symbol(s) HGNC5781, IGKV224, A23
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text member of the cluster of IGKV genes located at the proximal end of IGK@ (see symbol IGK@)
MAPPING cloned Y linked N status provisional
Physical map
IGKV7-3 2p11.2 immunoglobulin kappa variable 7-3 IGKV2-4 2p11.2 immunoglobulin kappa variable 2-4 IGKV1-5 2p11.2 immunoglobulin kappa variable 1-5 IGKV1-6 2p11.2 immunoglobulin kappa variable 1-6 IGKV3-7 2p11.2 immunoglobulin kappa variable 3-7 IGKV1-8 2p11.2 immunoglobulin kappa variable 1-8 IGKV1-9 2p11.2 immunoglobulin kappa variable 1-9 IGKV2-10 2p11.2 immunoglobulin kappa variable 2-10 IGKV3-11 2p11.2 immunoglobulin kappa variable 3-11 IGKV1-12 2p11.2 immunoglobulin kappa variable 1-12 IGKV1-13 2p11.2 immunoglobulin kappa variable 1-13 IGKV2-14 2p11.2 immunoglobulin kappa variable 2-14 IGKV3-15 2p11.2 immunoglobulin kappa variable 3-15 IGKV1-16 2p11.2 immunoglobulin kappa variable 1-16 IGKV1-17 2p11.2 immunoglobulin kappa variable 1-17 IGKV2-18 2p11.2 immunoglobulin kappa variable 2-18 IGKV2-19 2p11.2 immunoglobulin kappa variable 2-19 IGKV3-20 2p11.2 immunoglobulin kappa variable 3-20 IGKV6-21 2p11.2 immunoglobulin kappa variable 6-21 IGKV1-22 2p11.2 immunoglobulin kappa variable 1-22 IGKV2-23 2p11.2 immunoglobulin kappa variable 2-23 IGKV2-24 2p11.2 immunoglobulin kappa variable 2-24 IGKV3-25 2p11.2 immunoglobulin kappa variable 3-25 IGKV2-26 2p11.2 immunoglobulin kappa variable 2-26 IGKV1-27 2p11.2 immunoglobulin kappa variable 1-27 IGKV2-28 2p11.2 immunoglobulin kappa variable 2-28 IGKV2-29 2p11.2 immunoglobulin kappa variable 2-29 IGKV2-30 2p11.2 immunoglobulin kappa variable 2-30 IGKV3-31 2p11.2 immunoglobulin kappa variable 3-31 IGKV1-32 2p11.2 immunoglobulin kappa variable 1-32 IGKV1-33 2p11.2 immunoglobulin kappa variable 1-33 IGKV3-34 2p11.2 immunoglobulin kappa variable 3-34 IGKV1-35 2p11.2 immunoglobulin kappa variable 1-35 IGKV2-36 2p11.2 immunoglobulin kappa variable 2-36 IGKV1-37 2p11.2 immunoglobulin kappa variable 1-37
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
 spleen    
 thymus    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood/Hematopoieticbone marrow   
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a sequence of some 110 aminoacids folded to form a compact immunoglobulin domain with both ends joined together by a disulfide bond
  • made of three hypervariable regions (complementary-determining regions) located on the N terminal part of the sequence
  • the remaining part being relatively constant and forming the framework
  • HOMOLOGY
    Homologene
    FAMILY Immunoglobulin superfamily
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • forming the antigen binding site together with the cognate region of the light chain
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text humoral immunity, antibody synthesis
    PATHWAY
    metabolism
    signaling
    a component
  • C-terminal end covalently bound to the DJ segment by the V(D)J recombination system (see RAG1, RAG2)
  • during the process, a random loss or gain of nucleotides occurs (junctional diversification)
  • bound by a disulfide bond to a variable light chain
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C-terminal end covalently bound to the DJ segment by the V(D)J recombination system (see RAG1, RAG2)
  • during the process, a random loss or gain of nucleotides occurs (junctional diversification)
  • bound by a disulfide bond to a variable light chain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS